000078998 001__ 78998
000078998 005__ 20200716101453.0
000078998 0247_ $$2doi$$a10.1039/c8bm01600c
000078998 0248_ $$2sideral$$a111465
000078998 037__ $$aART-2019-111465
000078998 041__ $$aeng
000078998 100__ $$aMartí Coma-Cros, E.
000078998 245__ $$aMicelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery
000078998 260__ $$c2019
000078998 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078998 5203_ $$aBiomaterials for antimalarial drug transport still need to be investigated in order to attain nanocarriers that can tackle essential issues related to malaria treatment, e.g. complying with size requirements and targeting specificity for their entry into Plasmodium-infected red blood cells (pRBCs), and limiting premature drug elimination or drug resistance evolution. Two types of dendritic macromolecule that can form vehicles suitable for antimalarial drug transport are herein explored. A new hybrid dendritic-linear-dendritic block copolymer based on Pluronic® F127 and amino terminated 2, 2'-bis(glycyloxymethyl)propionic acid dendrons with a poly(ester amide) skeleton (HDLDBC-bGMPA) and an amino terminated dendronized hyperbranched polymer with a polyester skeleton derived from 2, 2'-bis(hydroxymethyl)propionic acid (DHP-bMPA) have provided self-assembled and unimolecular micelles. Both types of micelle carrier are biocompatible and exhibit appropriate sizes to enter into pRBCs. Targeting studies have revealed different behaviors for each nanocarrier that may open new perspectives for antimalarial therapeutic approaches. Whereas DHP-bMPA exhibits a clear targeting specificity for pRBCs, HDLDBC-bGMPA is incorporated by all erythrocytes. It has also been observed that DHP-bMPA and HDLDBC-bGMPA incorporate into human umbilical vein endothelial cells with different subcellular localization, i.e. cytosolic and nuclear, respectively. Drug loading capacity and encapsulation efficiencies for the antimalarial compounds chloroquine, primaquine and quinacrine ranging from 30% to 60% have been determined for both carriers. The resulting drug-loaded nanocarriers have been tested for their capacity to inhibit Plasmodium growth in in vitro and in vivo assays.
000078998 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/EC/H2020/712754/EU/Postdoctoral Programme in Bioengineering Excellence Scientific Training/BEST$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 712754-BEST$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/BIO2014-52872-R$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/CTQ2015-70174-P$$9info:eu-repo/grantAgreement/ES/MCIU-FEDER/MAT2015-66208-C3-1-P$$9info:eu-repo/grantAgreement/ES/MCIU/FPU12-05210$$9info:eu-repo/grantAgreement/ES/MINECO/SEV-2014-0425
000078998 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078998 590__ $$a6.183$$b2019
000078998 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b6 / 38 = 0.158$$c2019$$dQ1$$eT1
000078998 592__ $$a1.437$$b2019
000078998 593__ $$aMaterials Science (miscellaneous)$$c2019$$dQ1
000078998 593__ $$aBiomedical Engineering$$c2019$$dQ1
000078998 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078998 700__ $$0(orcid)0000-0001-6584-6603$$aLancelot, A.
000078998 700__ $$0(orcid)0000-0003-0063-9456$$aSan Anselmo, M.$$uUniversidad de Zaragoza
000078998 700__ $$aNeves Borgheti-Cardoso, L.
000078998 700__ $$aValle-Delgado, J.J.
000078998 700__ $$0(orcid)0000-0001-9866-6633$$aSerrano, J.L.$$uUniversidad de Zaragoza
000078998 700__ $$aFernàndez-Busquets, X.
000078998 700__ $$0(orcid)0000-0001-7091-077X$$aSierra, T.$$uUniversidad de Zaragoza
000078998 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000078998 773__ $$g7, 4 (2019), 1661-1674$$pBiomater. sci.$$tBiomaterials science$$x2047-4830
000078998 8564_ $$s608990$$uhttps://zaguan.unizar.es/record/78998/files/texto_completo.pdf$$yVersión publicada
000078998 8564_ $$s106991$$uhttps://zaguan.unizar.es/record/78998/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078998 909CO $$ooai:zaguan.unizar.es:78998$$particulos$$pdriver
000078998 951__ $$a2020-07-16-09:07:57
000078998 980__ $$aARTICLE