000079011 001__ 79011
000079011 005__ 20240122154813.0
000079011 0247_ $$2doi$$a10.1108/NFS-02-2018-0062
000079011 0248_ $$2sideral$$a108528
000079011 037__ $$aART-2018-108528
000079011 041__ $$aeng
000079011 100__ $$aAllaoui, A.
000079011 245__ $$aFenugreek proteins and their hydrolysates prevent hypercholesterolemia and enhance the HDL antioxidant properties in rats
000079011 260__ $$c2018
000079011 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079011 5203_ $$aPurpose
This paper aims to investigate the in vivo hypocholesterolemic property of fenugreek proteins (FP), Purafect-fenugreek protein hydrolysate (PFPH) and Esperase-fenugreek protein hydrolysate (EFPH) on high cholesterol (HC)-fed rats.
Design/methodology/approach
Rats were randomized into five groups: four were fed for four weeks a hypercholesterolemic diet and the tested products were given by gavage. The fifth group was taken as control (C) receiving the same diet without cholesterol.
Findings
Results showed that the elevated aspartate aminotransferase activity in HC group plasma was significantly corrected by FP and EFPH administration (-33 per cent; p = 0.0003). HC liver lipids and total cholesterol (TC) contents were not markedly affected by FP and EFPH. However, liver triglycerides (TG) contents trended to decrease in FP rats vs HC (p = 0.07), while, the TG decrease was significant in groups fed the proteins hydrolysates (p = 0.02). On the other hand, serum TC and TG decreased by 53 per cent (p = 0.0003) and 20 per cent (p = 0.04), respectively, in FP treated rats compared to HC group. This decrease was associated with a high fecal cholesterol excretion (2.5-fold higher in FP vs HC; p = 0.0001). Likewise, EFPH-treated rats exhibited lower TC compared to HC rats (p = 0.004). The very low density lipoprotins was the main affected fraction in these two groups, while there were no significant difference in apolipoproteins (Apo) B, A-I and A-IV contents between the different groups, except in FP group, where Apo A-I and A-IV decreased by 26 and 17 per cent, respectively, compared to C rats (p = 0.02). The high density lipoproteins (HDL) of rats treated with proteins hydrolysates showed a better antioxidant property compared to those of HC rats, which was accompanied with an increase in paraoxonase activity when compared to HC group.
Originality/value
Unlike PFPH which had almost no effect, FPs and EFPH could constitute a nutraceutical ingredient in cardiovascular disease management.
000079011 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
000079011 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000079011 592__ $$a0.246$$b2018
000079011 593__ $$aNutrition and Dietetics$$c2018$$dQ3
000079011 593__ $$aFood Science$$c2018$$dQ3
000079011 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000079011 700__ $$0(orcid)0000-0002-8442-8041$$aBarranquero, C.
000079011 700__ $$aYahia, S.
000079011 700__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, L.V.$$uUniversidad de Zaragoza
000079011 700__ $$aBenomar, S.
000079011 700__ $$aJridi, M.
000079011 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza
000079011 700__ $$aRodriguez-Yoldi, M.J.
000079011 700__ $$aNasri, M.
000079011 700__ $$aOsada, J.
000079011 700__ $$aBoualga, A.
000079011 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000079011 773__ $$g48, 6 (2018), 973-989$$pNutr. food sci.$$tNutrition and Food Science$$x0034-6659
000079011 8564_ $$s226766$$uhttps://zaguan.unizar.es/record/79011/files/texto_completo.pdf$$yPostprint
000079011 8564_ $$s65344$$uhttps://zaguan.unizar.es/record/79011/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000079011 909CO $$ooai:zaguan.unizar.es:79011$$particulos$$pdriver
000079011 951__ $$a2024-01-22-15:32:21
000079011 980__ $$aARTICLE