000079057 001__ 79057
000079057 005__ 20230914083231.0
000079057 0247_ $$2doi$$a10.1093/ofid/ofz036
000079057 0248_ $$2sideral$$a111336
000079057 037__ $$aART-2019-111336
000079057 041__ $$aeng
000079057 100__ $$aMendoza, Carmen de
000079057 245__ $$aClinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
000079057 260__ $$c2019
000079057 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079057 5203_ $$aBackground: although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods: a nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results: a total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions: given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
000079057 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000079057 590__ $$a3.656$$b2019
000079057 591__ $$aIMMUNOLOGY$$b68 / 158 = 0.43$$c2019$$dQ2$$eT2
000079057 591__ $$aMICROBIOLOGY$$b45 / 133 = 0.338$$c2019$$dQ2$$eT2
000079057 591__ $$aINFECTIOUS DISEASES$$b28 / 93 = 0.301$$c2019$$dQ2$$eT1
000079057 592__ $$a1.449$$b2019
000079057 593__ $$aOncology$$c2019$$dQ1
000079057 593__ $$aNeurology (clinical)$$c2019$$dQ1
000079057 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000079057 700__ $$aPirón, María
000079057 700__ $$aGonzález, Rocío
000079057 700__ $$aJiménez, Ana
000079057 700__ $$aCaballero, Estrella
000079057 700__ $$aRoc, Lourdes
000079057 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, Rafael$$uUniversidad de Zaragoza
000079057 700__ $$aRamos, José Manuel
000079057 700__ $$aSoriano, Vicente
000079057 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000079057 773__ $$g6, 2 (2019), ofz036 [4 pp]$$pOpen Forum Infectious Diseases$$tOpen Forum Infectious Diseases$$x2328-8957
000079057 8564_ $$s107669$$uhttps://zaguan.unizar.es/record/79057/files/texto_completo.pdf$$yVersión publicada
000079057 8564_ $$s135925$$uhttps://zaguan.unizar.es/record/79057/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000079057 909CO $$ooai:zaguan.unizar.es:79057$$particulos$$pdriver
000079057 951__ $$a2023-09-13-10:44:23
000079057 980__ $$aARTICLE