79057 20230914083231.0 doi 10.1093/ofid/ofz036 sideral 111336 ART-2019-111336 eng Mendoza, Carmen de Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain 2019 Access copy available to the general public Unrestricted Background: although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods: a nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results: a total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions: given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.656 2019 IMMUNOLOGY 68 / 158 = 0.43 2019 Q2 T2 MICROBIOLOGY 45 / 133 = 0.338 2019 Q2 T2 INFECTIOUS DISEASES 28 / 93 = 0.301 2019 Q2 T1 1.449 2019 Oncology 2019 Q1 Neurology (clinical) 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pirón, María González, Rocío Jiménez, Ana Caballero, Estrella Roc, Lourdes Benito, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Ramos, José Manuel Soriano, Vicente 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 6, 2 (2019), ofz036 [4 pp] Open Forum Infectious Diseases Open Forum Infectious Diseases 2328-8957 107669 http://zaguan.unizar.es/record/79057/files/texto_completo.pdf Versión publicada 135925 http://zaguan.unizar.es/record/79057/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:79057 articulos driver 2023-09-13-10:44:23 ARTICLE