000079081 001__ 79081
000079081 005__ 20191127155454.0
000079081 0247_ $$2doi$$a10.1021/acssuschemeng.8b00401
000079081 0248_ $$2sideral$$a106466
000079081 037__ $$aART-2018-106466
000079081 041__ $$aeng
000079081 100__ $$0(orcid)0000-0003-2585-0346$$aAlbisa, A.$$uUniversidad de Zaragoza
000079081 245__ $$aSustainable Production of Drug-Loaded Particles by Membrane Emulsification
000079081 260__ $$c2018
000079081 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079081 5203_ $$aAs the field of drug delivery is expanding into consumer products, it is essential to advance in the development of efficient synthesis technologies while preserving, at the same time, human health and the environment for future generations. Here, the sustainable development of polymeric particles for drug delivery is described. Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) based particles containing dexamethasone were produced by membrane emulsification-solvent diffusion methods. The ability of the synthesis process to control particle-size distribution and morphology and its green impactful (energy consumption, simple (sEF) and complete (cEF) E factor) were evaluated. Particles with sufficiently narrow distribution in their droplet size and mean diameter similar to the membrane pore diameter were produced by increasing the dispersed phase flux to 12.84 L h-1 m-2, minimizing the maximum shear stress to 1.12 Pa and the energy consumption to 3.96 × 105 J m-3. The impact of the solvent used on size distribution, particles morphology and green performance scores was also studied. More uniform particles, with dense and slightly rough surface, high encapsulation efficiency and drug loading were obtained by replacing dichloromethane with ethyl acetate. The E factor was also decreased by 80%. Results demonstrated that membrane emulsification is an environmentally improved method for the production of drug delivery systems with enormous impact in terms of formulation quality, energy consumption reduction and waste minimization.
000079081 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN$$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM$$9info:eu-repo/grantAgreement/EUR/ERASMUS/EUDIME-2011-0014
000079081 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000079081 590__ $$a6.97$$b2018
000079081 591__ $$aENGINEERING, CHEMICAL$$b9 / 138 = 0.065$$c2018$$dQ1$$eT1
000079081 591__ $$aGREEN & SUSTAINABLE SCIENCE & TECHNOLOGY$$b5 / 35 = 0.143$$c2018$$dQ1$$eT1
000079081 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b26 / 172 = 0.151$$c2018$$dQ1$$eT1
000079081 592__ $$a1.666$$b2018
000079081 593__ $$aChemical Engineering (miscellaneous)$$c2018$$dQ1
000079081 593__ $$aRenewable Energy, Sustainability and the Environment$$c2018$$dQ1
000079081 593__ $$aEnvironmental Chemistry$$c2018$$dQ1
000079081 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000079081 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000079081 700__ $$aPiacentini, E.
000079081 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000079081 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000079081 700__ $$aGiorno, L.
000079081 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000079081 773__ $$g6, 5 (2018), 6663-6674$$pACS sustain. chem. & eng.$$tACS sustainable chemistry & engineering$$x2168-0485
000079081 8564_ $$s635265$$uhttps://zaguan.unizar.es/record/79081/files/texto_completo.pdf$$yPostprint
000079081 8564_ $$s67596$$uhttps://zaguan.unizar.es/record/79081/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000079081 909CO $$ooai:zaguan.unizar.es:79081$$particulos$$pdriver
000079081 951__ $$a2019-11-27-15:46:36
000079081 980__ $$aARTICLE