79081 20191127155454.0 doi 10.1021/acssuschemeng.8b00401 sideral 106466 ART-2018-106466 eng (orcid)0000-0003-2585-0346 Albisa, A. Universidad de Zaragoza Sustainable Production of Drug-Loaded Particles by Membrane Emulsification 2018 Access copy available to the general public Unrestricted As the field of drug delivery is expanding into consumer products, it is essential to advance in the development of efficient synthesis technologies while preserving, at the same time, human health and the environment for future generations. Here, the sustainable development of polymeric particles for drug delivery is described. Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) based particles containing dexamethasone were produced by membrane emulsification-solvent diffusion methods. The ability of the synthesis process to control particle-size distribution and morphology and its green impactful (energy consumption, simple (sEF) and complete (cEF) E factor) were evaluated. Particles with sufficiently narrow distribution in their droplet size and mean diameter similar to the membrane pore diameter were produced by increasing the dispersed phase flux to 12.84 L h-1 m-2, minimizing the maximum shear stress to 1.12 Pa and the energy consumption to 3.96 × 105 J m-3. The impact of the solvent used on size distribution, particles morphology and green performance scores was also studied. More uniform particles, with dense and slightly rough surface, high encapsulation efficiency and drug loading were obtained by replacing dichloromethane with ethyl acetate. The E factor was also decreased by 80%. Results demonstrated that membrane emulsification is an environmentally improved method for the production of drug delivery systems with enormous impact in terms of formulation quality, energy consumption reduction and waste minimization. info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/grantAgreement/EUR/ERASMUS/EUDIME-2011-0014 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.97 2018 ENGINEERING, CHEMICAL 9 / 138 = 0.065 2018 Q1 T1 GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY 5 / 35 = 0.143 2018 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 26 / 172 = 0.151 2018 Q1 T1 1.666 2018 Chemical Engineering (miscellaneous) 2018 Q1 Renewable Energy, Sustainability and the Environment 2018 Q1 Environmental Chemistry 2018 Q1 Chemistry (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Piacentini, E. (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza Giorno, L. 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 6, 5 (2018), 6663-6674 ACS sustain. chem. & eng. ACS sustainable chemistry & engineering 2168-0485 635265 http://zaguan.unizar.es/record/79081/files/texto_completo.pdf Postprint 67596 http://zaguan.unizar.es/record/79081/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79081 articulos driver 2019-11-27-15:46:36 ARTICLE