000079115 001__ 79115
000079115 005__ 20191212100700.0
000079115 0247_ $$2doi$$a10.1016/j.colsurfb.2018.02.031
000079115 0248_ $$2sideral$$a106482
000079115 037__ $$aART-2018-106482
000079115 041__ $$aeng
000079115 100__ $$aArriortua, O.K.
000079115 245__ $$aRGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia
000079115 260__ $$c2018
000079115 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079115 5203_ $$aTo improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a “click” chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target avß3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles.
000079115 536__ $$9info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2016-78266-P$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
000079115 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000079115 590__ $$a3.973$$b2018
000079115 591__ $$aBIOPHYSICS$$b15 / 72 = 0.208$$c2018$$dQ1$$eT1
000079115 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b11 / 32 = 0.344$$c2018$$dQ2$$eT2
000079115 591__ $$aCHEMISTRY, PHYSICAL$$b49 / 148 = 0.331$$c2018$$dQ2$$eT2
000079115 592__ $$a0.957$$b2018
000079115 593__ $$aBiotechnology$$c2018$$dQ1
000079115 593__ $$aColloid and Surface Chemistry$$c2018$$dQ1
000079115 593__ $$aSurfaces and Interfaces$$c2018$$dQ1
000079115 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ1
000079115 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000079115 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000079115 700__ $$aInsausti, M.
000079115 700__ $$aLezama, L.
000079115 700__ $$aGil de Muro, I.
000079115 700__ $$aGaraio, E.
000079115 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, J.M.$$uUniversidad de Zaragoza
000079115 700__ $$0(orcid)0000-0001-5559-8757$$aFratila, R.M.
000079115 700__ $$aMorales, M.P.
000079115 700__ $$aCosta, R.
000079115 700__ $$aEceiza, M.
000079115 700__ $$aSagartzazu-Aizpurua, M.
000079115 700__ $$aAizpurua, J.M.
000079115 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000079115 773__ $$g165 (2018), 315-324$$pColloids surf., B Biointerfaces$$tCOLLOIDS AND SURFACES B-BIOINTERFACES$$x0927-7765
000079115 8564_ $$s939273$$uhttps://zaguan.unizar.es/record/79115/files/texto_completo.pdf$$yPostprint
000079115 8564_ $$s54285$$uhttps://zaguan.unizar.es/record/79115/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000079115 909CO $$ooai:zaguan.unizar.es:79115$$particulos$$pdriver
000079115 951__ $$a2019-12-12-10:03:49
000079115 980__ $$aARTICLE