79115 20191212100700.0 doi 10.1016/j.colsurfb.2018.02.031 sideral 106482 ART-2018-106482 eng Arriortua, O.K. RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia 2018 Access copy available to the general public Unrestricted To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a “click” chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target avß3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles. info:eu-repo/grantAgreement/ES/DGA/Fondo Social DGA-grupos DGA info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2016-78266-P info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.973 2018 BIOPHYSICS 15 / 72 = 0.208 2018 Q1 T1 MATERIALS SCIENCE, BIOMATERIALS 11 / 32 = 0.344 2018 Q2 T2 CHEMISTRY, PHYSICAL 49 / 148 = 0.331 2018 Q2 T2 0.957 2018 Biotechnology 2018 Q1 Colloid and Surface Chemistry 2018 Q1 Surfaces and Interfaces 2018 Q1 Physical and Theoretical Chemistry 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Insausti, M. Lezama, L. Gil de Muro, I. Garaio, E. (orcid)0000-0003-1081-8482 de la Fuente, J.M. Universidad de Zaragoza (orcid)0000-0001-5559-8757 Fratila, R.M. Morales, M.P. Costa, R. Eceiza, M. Sagartzazu-Aizpurua, M. Aizpurua, J.M. 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 165 (2018), 315-324 Colloids surf., B Biointerfaces COLLOIDS AND SURFACES B-BIOINTERFACES 0927-7765 939273 http://zaguan.unizar.es/record/79115/files/texto_completo.pdf Postprint 54285 http://zaguan.unizar.es/record/79115/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79115 articulos driver 2019-12-12-10:03:49 ARTICLE