79125 20200113145619.0 doi 10.1007/s10096-017-3129-y sideral 106556 ART-2018-106556 eng Lorente, L. Sustained high serum caspase-3 concentrations and mortality in septic patients 2018 Access copy available to the general public Unrestricted Caspase-3 is the main executor of the apoptotic process. Higher serum caspase-3 concentrations in non-survivor compared to survivor septic patients have been found. The objectives of this work (with the increase of sample size to 308 patients, and the determination of serum caspase-3 concentrations also on days 4 and 8 of diagnosis of severe sepsis) were to know whether an association between serum caspase-3 concentrationss during the first week, degree of apoptosis, sepsis severity, and sepsis mortality exists. We collected serum samples of 308 patients with severe sepsis from eight intensive care units on days 1, 4 and 8 to measure concentrations of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18 (to assess degree of apoptosis). End point was 30-day mortality. We found higher serum concentrations of caspase-3 and CCCK-18 in non-survivors compared to survivors on days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001). We found an association between serum caspase-3 concentrations on days 1, 4 and 8 of severe sepsis diagnosis and serum CCCK-18 concentrations (p < 0.001), SOFA (p < 0.001), serum acid lactic concentrations (p < 0.001), and 30-day sepsis mortality (p < 0.001). The new findings of this work were that an association between serum caspase-3 concentrations during the first week, apoptosis degree, sepsis severity, and sepsis mortality exists. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/INT16-00165 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI14-00220 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.591 2018 MICROBIOLOGY 78 / 133 = 0.586 2018 Q3 T2 INFECTIOUS DISEASES 46 / 89 = 0.517 2018 Q3 T2 1.208 2018 Infectious Diseases 2018 Q1 Microbiology (medical) 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Martín, M.M. Pérez-Cejas, A. González-Rivero, A.F. López, R.O. Ferreres, J. Solé-Violán, J. (orcid)0000-0002-3312-9383 Labarta, L. Universidad de Zaragoza Díaz, C. Palmero, S. Jiménez, A. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 37, 2 (2018), 281-288 Eur. j. clin. microbiol. infect. dis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 0934-9723 758298 http://zaguan.unizar.es/record/79125/files/texto_completo.pdf Postprint 73453 http://zaguan.unizar.es/record/79125/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79125 articulos driver 2020-01-13-14:54:52 ARTICLE