doi:10.1016/j.fct.2018.07.014engLópez-Gallardo, E.Emperador, S.Hernández-Ainsa, C.Montoya, J.Bayona-Bafaluy, M.P.Ruiz-Pesini, E.Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutationsART-2018-107038Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered.2018http://zaguan.unizar.es/record/7932610.1016/j.fct.2018.07.014http://zaguan.unizar.es/record/79326oai:zaguan.unizar.es:79326info:eu-repo/grantAgreement/ES/DGA-FEDER/B33-17Rinfo:eu-repo/grantAgreement/ES/ISCIII/PI14-00070info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166info:eu-repo/grantAgreement/ES/ISCIII/P114-00005FOOD AND CHEMICAL TOXICOLOGY 120 (2018), 89-97by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess