79326 20200217133051.0 doi 10.1016/j.fct.2018.07.014 sideral 107038 ART-2018-107038 eng (orcid)0000-0002-3217-1424 López-Gallardo, E. Universidad de Zaragoza Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations 2018 Access copy available to the general public Unrestricted Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered. info:eu-repo/grantAgreement/ES/DGA-FEDER/B33-17R info:eu-repo/grantAgreement/ES/ISCIII/PI14-00070 info:eu-repo/grantAgreement/ES/ISCIII/PI17-00021 info:eu-repo/grantAgreement/ES/ISCIII/PI17-00166 info:eu-repo/grantAgreement/ES/ISCIII/P114-00005 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.775 2018 TOXICOLOGY 18 / 93 = 0.194 2018 Q1 T1 FOOD SCIENCE & TECHNOLOGY 21 / 135 = 0.156 2018 Q1 T1 0.916 2018 Food Science 2018 Q1 Toxicology 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-5964-6138 Emperador, S. Universidad de Zaragoza (orcid)0000-0003-3524-5158 Hernández-Ainsa, C. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Montoya, J. Universidad de Zaragoza (orcid)0000-0002-8585-6371 Bayona-Bafaluy, M.P. Universidad de Zaragoza (orcid)0000-0002-0269-7337 Ruiz-Pesini, E. Universidad de Zaragoza 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 120 (2018), 89-97 Food chem. toxicol. FOOD AND CHEMICAL TOXICOLOGY 0278-6915 631490 http://zaguan.unizar.es/record/79326/files/texto_completo.pdf Postprint 8683 http://zaguan.unizar.es/record/79326/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79326 articulos driver 2020-02-17-12:42:59 ARTICLE