79329 20200117221635.0 doi 10.1021/acsami.8b02994 sideral 107173 ART-2018-107173 eng (orcid)0000-0002-0595-5514 Garcia-Salinas, S. Universidad de Zaragoza Rapid on-Chip Assembly of Niosomes: Batch versus Continuous Flow Reactors 2018 Access copy available to the general public Unrestricted The large-scale continuous production of niosomes remains challenging. The inherent drawbacks of batch processes such as large particle polydispersity and reduced batch-to-batch reproducibility are here overcome by using commercially available microfluidic reactors. Compared to the traditional batch-based film hydration method, herein, we demonstrate that it is possible to carry out the homogeneous, large-scale (up to 120 mg/min) production of niosomes using two different synthesis techniques (the thin film hydration method and the emulsification technique). Niosomes particle size can be controlled depending on the need by varying the synthesis temperature. The high cytocompatibility of the resulting niosomes was also demonstrated in this work on three different somatic cell lines. For the first time, the structure of the niosome multilamellar shell was also elucidated using high-resolution transmission electron microscopy (HR-STEM) as well as their colloidal stability over time (6 weeks) under different storage conditions. The morphology of cryo-protected or as-made niosomes was also evaluated by HR-STEM after freeze-drying. Finally, the dual ability of those synthetic, nonionic, surfactant-based vesicles to carry both hydrophilic and hydrophobic molecules was also here demonstrated by using laser scanning confocal microscopy. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 8.456 2018 NANOSCIENCE & NANOTECHNOLOGY 16 / 94 = 0.17 2018 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 27 / 293 = 0.092 2018 Q1 T1 2.596 2018 Materials Science (miscellaneous) 2018 Q1 Nanoscience and Nanotechnology 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Himawan, E. (orcid)0000-0003-2293-363X Mendoza, G. (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 10, 22 (2018), 19197-19207 ACS appl. mater. interfaces ACS Applied Materials & Interfaces 1944-8244 1211701 http://zaguan.unizar.es/record/79329/files/texto_completo.pdf Postprint 70077 http://zaguan.unizar.es/record/79329/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79329 articulos driver 2020-01-17-22:01:37 ARTICLE