000079512 001__ 79512 000079512 005__ 20210121114506.0 000079512 0247_ $$2doi$$a10.1016/j.chroma.2014.12.074 000079512 0248_ $$2sideral$$a89672 000079512 037__ $$aART-2015-89672 000079512 041__ $$aeng 000079512 100__ $$0(orcid)0000-0002-8934-3979$$aGracia-Moreno, E. 000079512 245__ $$aDetermination of 2-, 3-, 4-methylpentanoic and cyclohexanecarboxylic acids in wine: development of a selective method based on solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry and its application to different wines and alcoholic beverages 000079512 260__ $$c2015 000079512 5060_ $$aAccess copy available to the general public$$fUnrestricted 000079512 5203_ $$aA method to analyse 2-methylpentanoic, 3-methylpentanoic and 4-methylpentanoic acids as well as cyclohexanecarboxylic acid has been developed and applied to wine and other alcoholic beverages. Selective isolation with solid phase extraction, derivatization with 2,3,4,5,6-pentafluorobenzyl bromide at room temperature for 30 minutes, and further analysis by gas chromatography-mass spectrometry in negative chemical ionization mode provides detection limits between 0.4 and 2.4 ng/L. Good linearity up to 3.6 µg/L, satisfactory reproducibility (RSD < 10%) and signal recovery of around 100% represent a robust method of analysis. Concentration data of these analytes in wine and other alcoholic beverages are reported for the first time. The levels found ranged from the method detection limits to 2630 ng/L, 2040 ng/L and 3810 ng/L for 2-, 3- and 4- methylpentanoic acids, respectively, and to 1780 ng/L for cyclohexanecarboxylic acid. There are significant differences depending on the type of wine or beverage. Distilled beverages, beer and aged wines have higher contents in methylpentanoic and cyclohexanecarboxylic acids. 000079512 536__ $$9info:eu-repo/grantAgreement/ES/CICYT/AGL2010-22355-C02-01$$9info:eu-repo/grantAgreement/ES/MEC/FPU-AP2008-03811 000079512 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000079512 590__ $$a3.926$$b2015 000079512 591__ $$aCHEMISTRY, ANALYTICAL$$b11 / 75 = 0.147$$c2015$$dQ1$$eT1 000079512 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b14 / 77 = 0.182$$c2015$$dQ1$$eT1 000079512 592__ $$a1.693$$b2015 000079512 593__ $$aAnalytical Chemistry$$c2015$$dQ1 000079512 593__ $$aOrganic Chemistry$$c2015$$dQ1 000079512 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1 000079512 593__ $$aBiochemistry$$c2015$$dQ1 000079512 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000079512 700__ $$0(orcid)0000-0002-0730-6606$$aLópez, R.$$uUniversidad de Zaragoza 000079512 700__ $$0(orcid)0000-0002-4353-2483$$aFerreira, V.$$uUniversidad de Zaragoza 000079512 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000079512 773__ $$g1381 (2015), 210-218 [42 p.]$$pJ. chromatogr. A$$tJournal of Chromatography A$$x0021-9673 000079512 8564_ $$s477182$$uhttps://zaguan.unizar.es/record/79512/files/texto_completo.pdf$$yPostprint 000079512 8564_ $$s56594$$uhttps://zaguan.unizar.es/record/79512/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000079512 909CO $$ooai:zaguan.unizar.es:79512$$particulos$$pdriver 000079512 951__ $$a2021-01-21-10:54:30 000079512 980__ $$aARTICLE