79512 20210121114506.0 doi 10.1016/j.chroma.2014.12.074 sideral 89672 ART-2015-89672 eng (orcid)0000-0002-8934-3979 Gracia-Moreno, E. Determination of 2-, 3-, 4-methylpentanoic and cyclohexanecarboxylic acids in wine: development of a selective method based on solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry and its application to different wines and alcoholic beverages 2015 Access copy available to the general public Unrestricted A method to analyse 2-methylpentanoic, 3-methylpentanoic and 4-methylpentanoic acids as well as cyclohexanecarboxylic acid has been developed and applied to wine and other alcoholic beverages. Selective isolation with solid phase extraction, derivatization with 2,3,4,5,6-pentafluorobenzyl bromide at room temperature for 30 minutes, and further analysis by gas chromatography-mass spectrometry in negative chemical ionization mode provides detection limits between 0.4 and 2.4 ng/L. Good linearity up to 3.6 µg/L, satisfactory reproducibility (RSD < 10%) and signal recovery of around 100% represent a robust method of analysis. Concentration data of these analytes in wine and other alcoholic beverages are reported for the first time. The levels found ranged from the method detection limits to 2630 ng/L, 2040 ng/L and 3810 ng/L for 2-, 3- and 4- methylpentanoic acids, respectively, and to 1780 ng/L for cyclohexanecarboxylic acid. There are significant differences depending on the type of wine or beverage. Distilled beverages, beer and aged wines have higher contents in methylpentanoic and cyclohexanecarboxylic acids. info:eu-repo/grantAgreement/ES/CICYT/AGL2010-22355-C02-01 info:eu-repo/grantAgreement/ES/MEC/FPU-AP2008-03811 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.926 2015 CHEMISTRY, ANALYTICAL 11 / 75 = 0.147 2015 Q1 T1 BIOCHEMICAL RESEARCH METHODS 14 / 77 = 0.182 2015 Q1 T1 1.693 2015 Analytical Chemistry 2015 Q1 Organic Chemistry 2015 Q1 Medicine (miscellaneous) 2015 Q1 Biochemistry 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-0730-6606 López, R. Universidad de Zaragoza (orcid)0000-0002-4353-2483 Ferreira, V. Universidad de Zaragoza 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 1381 (2015), 210-218 [42 p.] J. chromatogr. A Journal of Chromatography A 0021-9673 477182 http://zaguan.unizar.es/record/79512/files/texto_completo.pdf Postprint 56594 http://zaguan.unizar.es/record/79512/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:79512 articulos driver 2021-01-21-10:54:30 ARTICLE