000079516 001__ 79516
000079516 005__ 20200716101419.0
000079516 0247_ $$2doi$$a10.3390/ijms20112759
000079516 0248_ $$2sideral$$a111682
000079516 037__ $$aART-2019-111682
000079516 041__ $$aeng
000079516 100__ $$0(orcid)0000-0001-5193-7782$$aMoreno Martínez, Laura$$uUniversidad de Zaragoza
000079516 245__ $$aAre circulating cytokines reliable biomarkers for amyotrophic lateral sclerosis?
000079516 260__ $$c2019
000079516 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079516 5203_ $$aAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has no effective treatment. The lack of any specific biomarker that can help in the diagnosis or prognosis of ALS has made the identification of biomarkers an urgent challenge. Multiple panels have shown alterations in levels of numerous cytokines in ALS, supporting the contribution of neuroinflammation to the progressive motor neuron loss. However, none of them is fully sensitive and specific enough to become a universal biomarker for ALS. This review gathers the numerous circulating cytokines that have been found dysregulated in both ALS animal models and patients. Particularly, it highlights the opposing results found in the literature to date, and points out another potential application of inflammatory cytokines as therapeutic targets.
000079516 536__ $$9info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949
000079516 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000079516 590__ $$a4.556$$b2019
000079516 592__ $$a1.317$$b2019
000079516 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b48 / 177 = 0.271$$c2019$$dQ2$$eT1
000079516 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000079516 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b74 / 297 = 0.249$$c2019$$dQ1$$eT1
000079516 593__ $$aPhysical and Theoretical Chemistry$$c2019$$dQ1
000079516 593__ $$aComputer Science Applications$$c2019$$dQ1
000079516 593__ $$aInorganic Chemistry$$c2019$$dQ1
000079516 593__ $$aSpectroscopy$$c2019$$dQ1
000079516 593__ $$aOrganic Chemistry$$c2019$$dQ1
000079516 593__ $$aMolecular Biology$$c2019$$dQ2
000079516 593__ $$aCatalysis$$c2019$$dQ2
000079516 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000079516 700__ $$0(orcid)0000-0002-7277-4318$$aCalvo, Ana Cristina$$uUniversidad de Zaragoza
000079516 700__ $$0(orcid)0000-0001-8301-6902$$aMuñoz, María Jesús$$uUniversidad de Zaragoza
000079516 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000079516 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000079516 7102_ $$11005$$2315$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Farmacología
000079516 773__ $$g20, 11 (2019), [17 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000079516 8564_ $$s259682$$uhttps://zaguan.unizar.es/record/79516/files/texto_completo.pdf$$yVersión publicada
000079516 8564_ $$s107446$$uhttps://zaguan.unizar.es/record/79516/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000079516 909CO $$ooai:zaguan.unizar.es:79516$$particulos$$pdriver
000079516 951__ $$a2020-07-16-08:39:18
000079516 980__ $$aARTICLE