79516 20200716101419.0 doi 10.3390/ijms20112759 sideral 111682 ART-2019-111682 eng (orcid)0000-0001-5193-7782 Moreno Martínez, Laura Universidad de Zaragoza Are circulating cytokines reliable biomarkers for amyotrophic lateral sclerosis? 2019 Access copy available to the general public Unrestricted Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has no effective treatment. The lack of any specific biomarker that can help in the diagnosis or prognosis of ALS has made the identification of biomarkers an urgent challenge. Multiple panels have shown alterations in levels of numerous cytokines in ALS, supporting the contribution of neuroinflammation to the progressive motor neuron loss. However, none of them is fully sensitive and specific enough to become a universal biomarker for ALS. This review gathers the numerous circulating cytokines that have been found dysregulated in both ALS animal models and patients. Particularly, it highlights the opposing results found in the literature to date, and points out another potential application of inflammatory cytokines as therapeutic targets. info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.556 2019 1.317 2019 CHEMISTRY, MULTIDISCIPLINARY 48 / 177 = 0.271 2019 Q2 T1 Medicine (miscellaneous) 2019 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY 74 / 297 = 0.249 2019 Q1 T1 Physical and Theoretical Chemistry 2019 Q1 Computer Science Applications 2019 Q1 Inorganic Chemistry 2019 Q1 Spectroscopy 2019 Q1 Organic Chemistry 2019 Q1 Molecular Biology 2019 Q2 Catalysis 2019 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-7277-4318 Calvo, Ana Cristina Universidad de Zaragoza (orcid)0000-0001-8301-6902 Muñoz, María Jesús Universidad de Zaragoza (orcid)0000-0001-5687-6704 Osta, Rosario Universidad de Zaragoza 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 20, 11 (2019), [17 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 259682 http://zaguan.unizar.es/record/79516/files/texto_completo.pdf Versión publicada 107446 http://zaguan.unizar.es/record/79516/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:79516 articulos driver 2020-07-16-08:39:18 ARTICLE