Optimization of the synthesis of glycerol derived monoethers from glycidol by means of heterogeneous acid catalysis

Pires, Elisabet (Universidad de Zaragoza) ; García, José Ignacio ; Leal-Duaso, Alejandro ; Mayoral, José Antonio (Universidad de Zaragoza) ; García-Peiro, José Ignacio ; Velázquez, David

Resumen: We present an efficient and green methodology for the synthesis of glycerol monoethers, starting from glycidol and different alcohols, by means of heterogeneous acid catalysis. A scope of Brønsted and Lewis acid catalysts were applied to the benchmark reaction of glycidol and methanol. The selected catalysts were cationic exchangers, such as Nafion NR50, Dowex 50WX2, Amberlyst 15 and K10-Montmorillonite, both in their protonic form and exchanged with Al(III), Zn(II) and Fe(III). Thus, total conversions were reached in short times by using 1 and 5% mol catalyst loading and room temperature, without the need for excess glycidol or the presence of a solvent. Finally, these conditions and the best catalysts were successfully applied to the reaction of glycidol with several alcohols such as butanol or isopropanol.

Idioma: Inglés

DOI: 10.3390/molecules23112887

Año: 2018

Publicado en: Molecules 23, 11 (2018), [10 pp]
ISSN: 1420-3049

Factor impacto JCR: 3.06 (2018)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 67 / 172 = 0.39 (2018) - Q2 - T2
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 133 / 294 = 0.452 (2018) - Q2 - T2

Factor impacto SCIMAGO: 0.757 - Analytical Chemistry (Q1) - Chemistry (miscellaneous) (Q1) - Drug Discovery (Q1) - Physical and Theoretical Chemistry (Q1) - Molecular Medicine (Q1) - Organic Chemistry (Q1) - Pharmaceutical Science (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E37-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52367-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)