000079571 001__ 79571
000079571 005__ 20210820090344.0
000079571 0247_ $$2doi$$a10.1109/JBHI.2018.2851299
000079571 0248_ $$2sideral$$a107422
000079571 037__ $$aART-2018-107422
000079571 041__ $$aeng
000079571 100__ $$0(orcid)0000-0003-0226-4950$$aMartín Yebra, Alba$$uUniversidad de Zaragoza
000079571 245__ $$aQuantification of Ventricular Repolarization Variation for Sudden Cardiac Death Risk Stratification in Atrial Fibrillation
000079571 260__ $$c2018
000079571 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079571 5203_ $$aObjective: Atrial fibrillation (AF) rhythm gives rise to an irregular response in ventricular activity, preventing the use of standard ECG-derived risk markers based on ventricular repolarization heterogeneity under this particular condition. In this study we proposed new indices to quantify repolarization variations in AF patients, assessing their stratification performance in a chronic heart failure (CHF) population with AF. Methods: We developed a method based on a selective bin averaging technique. Consecutive beats preceded by a similar RR interval were selected, from which the average variation within the ST-T complex for each RR range was computed.We proposed two sets of indices: (i) the 2-beat index of ventricular repolarization variation, (I_V2), computed from pairs of stable consecutive beats; and (ii) the 3-beat indices of ventricular repolarization variation, computed in triplets of stable consecutive beats (I_V3). Results: These indices showed a significant association with sudden cardiac death (SCD) outcome in the study population. In addition, risk assessment based on the combination of the proposed indices improved stratification performance compared to their individual potential. Conclusion: Patients with enhanced ventricular repolarization variation computed in terms of the proposed indices were successfully associated to a higher SCD incidence in our study population, evidencing their prognostic value. Significance: using a simple ambulatory ECG recording, it is possible to stratify AF patients at risk of SCD, which may help cardiologists in adopting most effective therapeutic strategies, with a positive impact in both the patient and healthcare systems.
000079571 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS
000079571 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000079571 590__ $$a4.217$$b2018
000079571 591__ $$aCOMPUTER SCIENCE, INFORMATION SYSTEMS$$b19 / 155 = 0.123$$c2018$$dQ1$$eT1
000079571 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b5 / 59 = 0.085$$c2018$$dQ1$$eT1
000079571 591__ $$aMEDICAL INFORMATICS$$b4 / 26 = 0.154$$c2018$$dQ1$$eT1
000079571 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b16 / 106 = 0.151$$c2018$$dQ1$$eT1
000079571 592__ $$a1.122$$b2018
000079571 593__ $$aBiotechnology$$c2018$$dQ1
000079571 593__ $$aHealth Information Management$$c2018$$dQ1
000079571 593__ $$aElectrical and Electronic Engineering$$c2018$$dQ1
000079571 593__ $$aComputer Science Applications$$c2018$$dQ1
000079571 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion
000079571 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000079571 700__ $$aCygankiewicz, Iwona
000079571 700__ $$aBayés-de-Luna, Antoni
000079571 700__ $$aCaiani, Enrico G.
000079571 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza
000079571 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000079571 773__ $$g23, 3 (2018), 1049 - 1057$$pIEEE j. biomed. health inform.$$tIEEE journal of biomedical and health informatics$$x2168-2194
000079571 8564_ $$s398866$$uhttps://zaguan.unizar.es/record/79571/files/texto_completo.pdf$$yPreprint
000079571 8564_ $$s147385$$uhttps://zaguan.unizar.es/record/79571/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint
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000079571 951__ $$a2021-08-20-08:37:06
000079571 980__ $$aARTICLE