000079590 001__ 79590
000079590 005__ 20210820090344.0
000079590 0247_ $$2doi$$a10.3389/fphys.2019.00620
000079590 0248_ $$2sideral$$a112221
000079590 037__ $$aART-2019-112221
000079590 041__ $$aeng
000079590 100__ $$0(orcid)0000-0002-7842-9611$$aMilagro, Javier$$uUniversidad de Zaragoza
000079590 245__ $$aAutonomic dysfunction increases cardiovascular risk in the presence of sleep apnea
000079590 260__ $$c2019
000079590 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079590 5203_ $$aThe high prevalence of sleep apnea syndrome (SAS) and its direct relationship with an augmented risk of cardiovascular disease (CVD) have raised SAS as a primary public health problem. For this reason, extensive research aiming to understand the interaction between both conditions has been conducted. The advances in non-invasive autonomic nervous system (ANS) monitoring through heart rate variability (HRV) analysis have revealed an increased sympathetic dominance in subjects suffering from SAS when compared with controls. Similarly, HRV analysis of subjects with CVD suggests altered autonomic activity. In this work, we investigated the altered autonomic control in subjects suffering from SAS and CVD simultaneously when compared with SAS patients, as well as the possibility that ANS assessment may be useful for the early stage identification of cardiovascular risk in subjects with SAS. The analysis was performed over 199 subjects from two independent datasets during night-time, and the effects of the physiological response following an apneic episode, sleep stages, and respiration on HRV were taken into account. Results, as measured by HRV, suggest a decreased sympathetic dominance in those subjects suffering from both conditions, as well as in subjects with SAS that will develop CVDs, which was reflected in a significantly reduced sympathovagal balance (p < 0.05). In this way, ANS monitoring could contribute to improve screening and diagnosis, and eventually aid in the phenotyping of patients, as an altered response might have direct implications on cardiovascular health.
000079590 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BES-2015-073694$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 745755-WECARMON$$9info:eu-repo/grantAgreement/EC/H2020/745755/EU/Wearable Cardiorespiratory Monitor/WECARMON$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS$$9info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN
000079590 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000079590 590__ $$a3.367$$b2019
000079590 591__ $$aPHYSIOLOGY$$b20 / 81 = 0.247$$c2019$$dQ1$$eT1
000079590 592__ $$a1.211$$b2019
000079590 593__ $$aPhysiology (medical)$$c2019$$dQ2
000079590 593__ $$aPhysiology$$c2019$$dQ2
000079590 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000079590 700__ $$aDeviaene, Margot
000079590 700__ $$0(orcid)0000-0001-7285-0715$$aGil, Eduardo$$uUniversidad de Zaragoza
000079590 700__ $$0(orcid)0000-0001-8742-0072$$aLazaro, Jesús$$uUniversidad de Zaragoza
000079590 700__ $$aBuyse, Bertien
000079590 700__ $$aTestelmans, Dries
000079590 700__ $$aBorzée, Pascal
000079590 700__ $$aWillems, Rik
000079590 700__ $$aVan Huffel, Sabine
000079590 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000079590 700__ $$aVaron, Carolina
000079590 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000079590 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000079590 773__ $$g10, Art. 620 (2019), [11 pp.]$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000079590 8564_ $$s1383136$$uhttps://zaguan.unizar.es/record/79590/files/texto_completo.pdf$$yVersión publicada
000079590 8564_ $$s11409$$uhttps://zaguan.unizar.es/record/79590/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000079590 909CO $$ooai:zaguan.unizar.es:79590$$particulos$$pdriver
000079590 951__ $$a2021-08-20-08:36:48
000079590 980__ $$aARTICLE