79590 20210820090344.0 doi 10.3389/fphys.2019.00620 sideral 112221 ART-2019-112221 eng Milagro, Javier Universidad de Zaragoza (orcid)0000-0002-7842-9611 Autonomic dysfunction increases cardiovascular risk in the presence of sleep apnea 2019 Access copy available to the general public Unrestricted The high prevalence of sleep apnea syndrome (SAS) and its direct relationship with an augmented risk of cardiovascular disease (CVD) have raised SAS as a primary public health problem. For this reason, extensive research aiming to understand the interaction between both conditions has been conducted. The advances in non-invasive autonomic nervous system (ANS) monitoring through heart rate variability (HRV) analysis have revealed an increased sympathetic dominance in subjects suffering from SAS when compared with controls. Similarly, HRV analysis of subjects with CVD suggests altered autonomic activity. In this work, we investigated the altered autonomic control in subjects suffering from SAS and CVD simultaneously when compared with SAS patients, as well as the possibility that ANS assessment may be useful for the early stage identification of cardiovascular risk in subjects with SAS. The analysis was performed over 199 subjects from two independent datasets during night-time, and the effects of the physiological response following an apneic episode, sleep stages, and respiration on HRV were taken into account. Results, as measured by HRV, suggest a decreased sympathetic dominance in those subjects suffering from both conditions, as well as in subjects with SAS that will develop CVDs, which was reflected in a significantly reduced sympathovagal balance (p < 0.05). In this way, ANS monitoring could contribute to improve screening and diagnosis, and eventually aid in the phenotyping of patients, as an altered response might have direct implications on cardiovascular health. info:eu-repo/grantAgreement/ES/CSIC-IMB-CNM/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS info:eu-repo/grantAgreement/EC/H2020/745755/EU/Wearable Cardiorespiratory Monitor/WECARMON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 745755-WECARMON info:eu-repo/grantAgreement/ES/MINECO/BES-2015-073694 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.367 2019 PHYSIOLOGY 20 / 81 = 0.247 2019 Q1 T1 1.211 2019 Physiology (medical) 2019 Q2 Physiology 2019 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Deviaene, Margot Gil, Eduardo Universidad de Zaragoza (orcid)0000-0001-7285-0715 Lazaro, Jesús Universidad de Zaragoza (orcid)0000-0001-8742-0072 Buyse, Bertien Testelmans, Dries Borzée, Pascal Willems, Rik Van Huffel, Sabine Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Varon, Carolina 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 10, Art. 620 (2019), [11 pp.] Front. physiol. FRONTIERS IN PHYSIOLOGY 1664-042X 1383136 http://zaguan.unizar.es/record/79590/files/texto_completo.pdf Versión publicada 11409 http://zaguan.unizar.es/record/79590/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:79590 articulos driver 2021-08-20-08:36:48 ARTICLE