000079616 001__ 79616 000079616 005__ 20230921135424.0 000079616 0247_ $$2doi$$a10.3389/fcell.2019.00079 000079616 0248_ $$2sideral$$a112312 000079616 037__ $$aART-2019-112312 000079616 041__ $$aeng 000079616 100__ $$aCabezas-Cruz, Alejandro 000079616 245__ $$aThe good, the bad and the tick 000079616 260__ $$c2019 000079616 5060_ $$aAccess copy available to the general public$$fUnrestricted 000079616 5203_ $$aHow tick-borne pathogens (TBPs) could help us understand cancer? The diversity of pathogens transmitted by ticks is higher than that of any other known arthropod vector and includes protozoa (e.g., Babesia spp. and Theileria spp.), bacteria (e.g., intracellular Rickettsia spp. and extracellular Borrelia spp.), viruses (e.g., Tick-borne encephalitis (TBE) and Crimean-Congo hemorrhagic fever (CCHF) virus), helminths (e.g., Cercopithifilaria) and, although less known, fungi (e.g., Dermatophilus) (Otranto et al., 2013; Brites-Neto et al., 2015; de la Fuente et al., 2017). TBPs have complex life cycles that involve vertebrate hosts and the ticks. Intracellular TBP infection triggers cellular and molecular responses that change host cell physiology in fundamental ways. Within vertebrate host cells, the apicomplexan parasites Theileria parva and Theileria annulata activate molecular pathways that result in increased production of reactive oxygen species (ROS), cell immortalization, cancer and host death. In contrast, infection by the rickettsia Anaplasma phagocytophilum inhibits apoptosis, block the production of ROS and results in a self-limiting infection that rarely is lethal for the host. Theileria spp. and A. phagocytophilum modulates host cell response by inducing transcriptional reprogramming of their vertebrate host cells, leukocytes. Transcriptional reprogramming is induced by pathogen-encoded effector proteins that modify host epigenetic pathways that affect not only gene transcription but also protein levels. 000079616 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000079616 590__ $$a5.201$$b2019 000079616 592__ $$a2.572$$b2019 000079616 591__ $$aDEVELOPMENTAL BIOLOGY$$b6 / 41 = 0.146$$c2019$$dQ1$$eT1 000079616 593__ $$aDevelopmental Biology$$c2019$$dQ1 000079616 591__ $$aCELL BIOLOGY$$b54 / 194 = 0.278$$c2019$$dQ2$$eT1 000079616 593__ $$aCell Biology$$c2019$$dQ1 000079616 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000079616 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, Agustín$$uUniversidad de Zaragoza 000079616 700__ $$aFuente, José de la 000079616 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000079616 773__ $$g7, Art. 79 (2019), [5 pp.]$$tFrontiers in Cell and Developmental Biology$$x2296-634X 000079616 8564_ $$s167965$$uhttps://zaguan.unizar.es/record/79616/files/texto_completo.pdf$$yVersión publicada 000079616 8564_ $$s11805$$uhttps://zaguan.unizar.es/record/79616/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000079616 909CO $$ooai:zaguan.unizar.es:79616$$particulos$$pdriver 000079616 951__ $$a2023-09-21-13:28:54 000079616 980__ $$aARTICLE