000079629 001__ 79629
000079629 005__ 20200716101445.0
000079629 0247_ $$2doi$$a10.3390/ma12071092
000079629 0248_ $$2sideral$$a112231
000079629 037__ $$aART-2019-112231
000079629 041__ $$aeng
000079629 100__ $$aComas, Laura
000079629 245__ $$aIntracellular delivery of biologically-active fungal metabolite gliotoxin using magnetic nanoparticles
000079629 260__ $$c2019
000079629 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079629 5203_ $$aGliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as a potential anti-tumor agent. Here we have developed a nanoparticle approach to enhance delivery of GT in tumor cells and establish a basis for its potential use as therapeutical drug. GT bound to magnetic nanoparticles (MNPs) retained a high anti-tumor activity, correlating with efficient intracellular delivery, which was increased in the presence of glucose. Our results show that the attachment of GT to MNPs by covalent bonding enhances intracellular GT delivery without affecting its biological activity. This finding represents the first step to use this potent anti-tumor agent in the treatment of cancer.
000079629 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/FJCI-2017-31629$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2017-83120-C2-1-R
000079629 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000079629 590__ $$a3.057$$b2019
000079629 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b132 / 314 = 0.42$$c2019$$dQ2$$eT2
000079629 592__ $$a0.647$$b2019
000079629 593__ $$aMaterials Science (miscellaneous)$$c2019$$dQ2
000079629 593__ $$aCondensed Matter Physics$$c2019$$dQ2
000079629 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000079629 700__ $$aPolo, Esther
000079629 700__ $$aDomingo, M. Pilar
000079629 700__ $$aHernandez, Yulán
000079629 700__ $$0(orcid)0000-0002-9730-2210$$aArias, Maykel
000079629 700__ $$aEsteban, Patricia
000079629 700__ $$0(orcid)0000-0003-3043-147X$$aMartinez-Lostao, Luis$$uUniversidad de Zaragoza
000079629 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julián$$uUniversidad de Zaragoza
000079629 700__ $$0(orcid)0000-0003-1081-8482$$aMartínez de la Fuente, Jesús
000079629 700__ $$0(orcid)0000-0001-6928-5516$$aGalvez, Eva M.
000079629 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Inmunología
000079629 773__ $$g12, 7 (2019), 1092 [17 pp]$$pMATERIALS$$tMaterials$$x1996-1944
000079629 8564_ $$s4095993$$uhttps://zaguan.unizar.es/record/79629/files/texto_completo.pdf$$yVersión publicada
000079629 8564_ $$s102363$$uhttps://zaguan.unizar.es/record/79629/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000079629 909CO $$ooai:zaguan.unizar.es:79629$$particulos$$pdriver
000079629 951__ $$a2020-07-16-09:02:12
000079629 980__ $$aARTICLE