000079677 001__ 79677
000079677 005__ 20200629114353.0
000079677 0247_ $$2doi$$a10.1177/1971400919857544
000079677 0248_ $$2sideral$$a112587
000079677 037__ $$aART-2019-112587
000079677 041__ $$aeng
000079677 100__ $$aFayed, Nicolás
000079677 245__ $$aChanges in metabolites in the brain of patients with fibromyalgia after treatment with an NMDA receptor antagonist
000079677 260__ $$c2019
000079677 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079677 5203_ $$aThe aims of this work were to evaluate whether the treatment of patients with fibromyalgia with memantine is associated with significant changes in metabolite concentrations in the brain, and to explore any changes in clinical outcome measures. Magnetic resonance spectroscopy was performed of the right anterior and posterior insula, both hippocampi and the posterior cingulate cortex. Questionnaires on pain, anxiety, depression, global function, quality of life and cognitive impairment were used. Ten patients were studied at baseline and after three months of treatment with memantine. Significant increases were observed in the following areas: N-acetylaspartate (4.47 at baseline vs. 4.71 at three months, p¿=¿0.02) and N-acetylaspartate+N-acetylaspartate glutamate in the left hippocampus (5.89 vs. 5.98; p¿=¿0.007); N-acetylaspartate+N-acetylaspartate glutamate in the right hippocampus (5.31 vs 5.79; p¿=¿0.01) and the anterior insula (7.56 vs. 7.70; p¿=¿0.033); glutamate+glutamine/creatine ratio in the anterior insula (2.03 vs. 2.17; p¿=¿0.022) and the posterior insula (1.77 vs. 2.00; p¿=¿0.004); choline/creatine ratio in the posterior cingulate (0.18 vs. 0.19; p¿=¿0.023); and creatine in the right hippocampus (3.60 vs. 3.85; p¿=¿0.007). At the three-month follow-up, memantine improved cognitive function assessed by the Cognition Mini-Exam (31.50, SD¿=¿2.95 vs. 34.40, SD¿=¿0.6; p¿=¿0.005), depression measured by the Hamilton Depression Scale (7.70, SD¿=¿0.81 vs. 7.56, SD¿=¿0.68; p¿=¿0.042) and severity of illness measured by the Clinical Global Impression severity scale (5.79, SD¿=¿0.96 vs. 5.31, SD¿=¿1.12; p¿=¿0.007). Depression, clinical global impression and cognitive function showed improvement with memantine. Magnetic resonance spectroscopy could be useful in monitoring response to the pharmacological treatment of fibromyalgia.
000079677 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B17-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0007-0005
000079677 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000079677 592__ $$a0.489$$b2019
000079677 593__ $$aMedicine (miscellaneous)$$c2019$$dQ2
000079677 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2019$$dQ3
000079677 593__ $$aNeurology (clinical)$$c2019$$dQ3
000079677 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000079677 700__ $$0(orcid)0000-0001-6565-9699$$aOliván, Bárbara$$uUniversidad de Zaragoza
000079677 700__ $$0(orcid)0000-0002-1690-4130$$aLopez del Hoyo, Yolanda$$uUniversidad de Zaragoza
000079677 700__ $$aAndrés, Eva
000079677 700__ $$0(orcid)0000-0001-5566-9746$$aPerez-Yus, Mari Cruz$$uUniversidad de Zaragoza
000079677 700__ $$aFayed, Alicia
000079677 700__ $$aAngel, Luisa F.
000079677 700__ $$aSerrano-Blanco, Antoni
000079677 700__ $$aRoca, Miquel
000079677 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia Campayo, Javier$$uUniversidad de Zaragoza
000079677 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000079677 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000079677 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000079677 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000079677 773__ $$g32, 6 (2019), 408-419$$pNeuroradiol. j.$$tNeuroradiology Journal$$x1971-4009
000079677 8564_ $$s1050771$$uhttps://zaguan.unizar.es/record/79677/files/texto_completo.pdf$$yVersión publicada
000079677 8564_ $$s108891$$uhttps://zaguan.unizar.es/record/79677/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000079677 909CO $$ooai:zaguan.unizar.es:79677$$particulos$$pdriver
000079677 951__ $$a2020-06-29-11:25:07
000079677 980__ $$aARTICLE