000079701 001__ 79701
000079701 005__ 20201028133238.0
000079701 0247_ $$2doi$$a10.1016/j.nlm.2018.08.013
000079701 0248_ $$2sideral$$a108648
000079701 037__ $$aART-2018-108648
000079701 041__ $$aeng
000079701 100__ $$aMontoliu, T.
000079701 245__ $$aThe relationship between cortisol and cognitive function in healthy older people: The moderating role of Apolipoprotein E polymorphism
000079701 260__ $$c2018
000079701 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079701 5203_ $$aThe Apolipoprotein E4 (ApoE-e4) allele has been suggested as the main risk factor for late onset Alzheimer''s disease (AD), whereas the ApoE-e2 allele has been proposed as a protective factor. These proposals have increased the interest in the effect of the ApoE genotype in healthy people. Additionally, high cortisol levels have been related to negative effects on cognition. However, few studies have investigated the relationship between cognitive performance and cortisol, taking into account the different ApoE alleles. For this reason, the aim of this study was to evaluate different cognitive domains (declarative and working memory, attention, and executive function) and their relationship with cortisol, considering the ApoE-e2, ApoE-e3, and ApoE-e4 alleles in healthy older people (55–77 years old). Two saliva samples were collected during the neuropsychological session to obtain cortisol levels and the ApoE genotype. Results showed an association between the ApoE genotype and declarative memory, specifically learning ability, where ApoE-e2 group performed better than ApoE-e4 and ApoE-e3 groups. No differences in cortisol levels were obtained considering the ApoE genotype. In addition, higher mean cortisol levels were related to a worse performance on declarative memory, for the whole sample, and when considering the three allelic variation, for the ApoE-e4 group. On the contrary, an increase of cortisol levels during the neuropsychological session was associated to a better performance on declarative memory for the whole sample, and for the ApoE-e3 group when considering the three alleles. Besides, ApoE-e3 group also showed an association between higher mean cortisol levels and a better attention performance. Therefore, our results suggest that carrying the ApoE-e4 allele may be a vulnerability factor in the adverse effects of Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation on cognition during aging, while ApoE-e3 allele could be associated to a more adaptive HPA axis response.
000079701 536__ $$9info:eu-repo/grantAgreement/ES/MEC/PSI2013-46889$$9info:eu-repo/grantAgreement/ES/MEC/PSI2016-78763
000079701 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000079701 590__ $$a3.01$$b2018
000079701 591__ $$aBEHAVIORAL SCIENCES$$b11 / 53 = 0.208$$c2018$$dQ1$$eT1
000079701 591__ $$aPSYCHOLOGY, MULTIDISCIPLINARY$$b25 / 137 = 0.182$$c2018$$dQ1$$eT1
000079701 591__ $$aPSYCHOLOGY$$b19 / 77 = 0.247$$c2018$$dQ1$$eT1
000079701 591__ $$aNEUROSCIENCES$$b126 / 266 = 0.474$$c2018$$dQ2$$eT2
000079701 592__ $$a1.732$$b2018
000079701 593__ $$aBehavioral Neuroscience$$c2018$$dQ1
000079701 593__ $$aExperimental and Cognitive Psychology$$c2018$$dQ1
000079701 593__ $$aCognitive Neuroscience$$c2018$$dQ1
000079701 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000079701 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000079701 700__ $$0(orcid)0000-0002-7048-3795$$aPulopulos, Matias M.
000079701 700__ $$aIvorra, J.L.
000079701 700__ $$aMartínez, M.J.
000079701 700__ $$aSalvador, A.
000079701 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000079701 773__ $$g155 (2018), 297-305$$pNeurobiol. learn. mem.$$tNEUROBIOLOGY OF LEARNING AND MEMORY$$x1074-7427
000079701 8564_ $$s890955$$uhttps://zaguan.unizar.es/record/79701/files/texto_completo.pdf$$yPostprint
000079701 8564_ $$s55050$$uhttps://zaguan.unizar.es/record/79701/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000079701 909CO $$ooai:zaguan.unizar.es:79701$$particulos$$pdriver
000079701 951__ $$a2020-10-28-13:23:58
000079701 980__ $$aARTICLE