000084147 001__ 84147
000084147 005__ 20240112142252.0
000084147 0247_ $$2doi$$a10.1111/acps.12966
000084147 0248_ $$2sideral$$a108806
000084147 037__ $$aART-2019-108806
000084147 041__ $$aeng
000084147 100__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza
000084147 245__ $$aClinically significant anxiety as a risk factor for dementia in the elderly community
000084147 260__ $$c2019
000084147 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084147 5203_ $$aObjective: To evaluate whether clinically significant anxiety is an independent risk factor for dementia, taking into account both depression among potentially confounding factors and the competing risk of death.
Method: During the Zaragoza Dementia and Depression (ZARADEMP) study, a random sample of community dwellers aged 55 years or older was assessed (n = 4803), and a two-wave, 4.5-year follow-up was completed. Geriatric Mental State (GMS)-AGECAT criteria were used to diagnose anxiety and DSM-IV criteria were applied to diagnose incident dementia. The multivariate Fine and Gray regression model was implemented to calculate dementia risk.
Results: Compared with non-cases (GMS-AGECAT criteria), the incidence rate of dementia was significantly higher in subcases of anxiety, and particularly significant in the cases of anxiety (incidence rate ratio (IRR): 2.77; P = 0.010). Cases of anxiety, but not subcases, at baseline were significantly associated with dementia risk (adjusted subdistribution hazard ratio (SHR): 2.7; P = 0.019).
Conclusion: Clinically significant anxiety is associated with an almost threefold increase in the risk of dementia in the population, even when controlling for depression and considering mortality in the competing risks model.
000084147 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103
000084147 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000084147 590__ $$a5.362$$b2019
000084147 591__ $$aPSYCHIATRY$$b14 / 140 = 0.1$$c2019$$dQ1$$eT1
000084147 591__ $$aPSYCHIATRY$$b20 / 154 = 0.13$$c2019$$dQ1$$eT1
000084147 592__ $$a2.516$$b2019
000084147 593__ $$aPsychiatry and Mental Health$$c2019$$dQ1
000084147 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000084147 700__ $$0(orcid)0000-0002-3360-7015$$aLopez-Anton, R.$$uUniversidad de Zaragoza
000084147 700__ $$0(orcid)0000-0003-2284-7862$$ade la Cámara, C.$$uUniversidad de Zaragoza
000084147 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza
000084147 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000084147 700__ $$aVillagrasa, B.
000084147 700__ $$0(orcid)0000-0002-0519-4962$$aBueno-Notivol, J.
000084147 700__ $$0(orcid)0000-0001-6836-1222$$aMarcos, G.
000084147 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000084147 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000084147 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000084147 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000084147 773__ $$g139, 1 (2019), 6-14$$pActa psychiatr. Scand.$$tActa Psychiatrica Scandinavica$$x0001-690X
000084147 8564_ $$s197427$$uhttps://zaguan.unizar.es/record/84147/files/texto_completo.pdf$$yPostprint
000084147 8564_ $$s41275$$uhttps://zaguan.unizar.es/record/84147/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000084147 909CO $$ooai:zaguan.unizar.es:84147$$particulos$$pdriver
000084147 951__ $$a2024-01-12-14:21:00
000084147 980__ $$aARTICLE