84147 20240112142252.0 doi 10.1111/acps.12966 sideral 108806 ART-2019-108806 eng Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Clinically significant anxiety as a risk factor for dementia in the elderly community 2019 Access copy available to the general public Unrestricted Objective: To evaluate whether clinically significant anxiety is an independent risk factor for dementia, taking into account both depression among potentially confounding factors and the competing risk of death. Method: During the Zaragoza Dementia and Depression (ZARADEMP) study, a random sample of community dwellers aged 55 years or older was assessed (n = 4803), and a two-wave, 4.5-year follow-up was completed. Geriatric Mental State (GMS)-AGECAT criteria were used to diagnose anxiety and DSM-IV criteria were applied to diagnose incident dementia. The multivariate Fine and Gray regression model was implemented to calculate dementia risk. Results: Compared with non-cases (GMS-AGECAT criteria), the incidence rate of dementia was significantly higher in subcases of anxiety, and particularly significant in the cases of anxiety (incidence rate ratio (IRR): 2.77; P = 0.010). Cases of anxiety, but not subcases, at baseline were significantly associated with dementia risk (adjusted subdistribution hazard ratio (SHR): 2.7; P = 0.019). Conclusion: Clinically significant anxiety is associated with an almost threefold increase in the risk of dementia in the population, even when controlling for depression and considering mortality in the competing risks model. info:eu-repo/grantAgreement/ES/DGA/B15-17R info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 5.362 2019 PSYCHIATRY 14 / 140 = 0.1 2019 Q1 T1 PSYCHIATRY 20 / 154 = 0.13 2019 Q1 T1 2.516 2019 Psychiatry and Mental Health 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Lopez-Anton, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 de la Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 Lobo, E. Universidad de Zaragoza (orcid)0000-0002-1252-2397 Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Villagrasa, B. Bueno-Notivol, J. (orcid)0000-0002-0519-4962 Marcos, G. (orcid)0000-0001-6836-1222 Lobo, A. Universidad de Zaragoza (orcid)0000-0002-9098-655X 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 139, 1 (2019), 6-14 Acta psychiatr. Scand. Acta Psychiatrica Scandinavica 0001-690X 197427 http://zaguan.unizar.es/record/84147/files/texto_completo.pdf Postprint 41275 http://zaguan.unizar.es/record/84147/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84147 articulos driver 2024-01-12-14:21:00 ARTICLE