000084152 001__ 84152
000084152 005__ 20250117145308.0
000084152 0247_ $$2doi$$a10.1021/acs.organomet.8b00601
000084152 0248_ $$2sideral$$a108815
000084152 037__ $$aART-2018-108815
000084152 041__ $$aeng
000084152 100__ $$aLuengo, Andrés
000084152 245__ $$aBioactive Heterobimetallic Re(I)/Au(I) Complexes Containing Bidentate N-Heterocyclic Carbenes
000084152 260__ $$c2018
000084152 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084152 5203_ $$aThe first cationic heterobimetallic complexes of the type fac-[Re(CO)3(NHC)(LAuPPh3)]+, where NHC is an imidazole pyridine-based carbene and L is 3-pyridylalkyne, 4-pyridylalkyne, or 5-ethynyl-1-methyl-1H-imidazole, have been synthesized together with their Re(I) precursors. All of them have showed similar emissive properties resulting from the presence of the NHC system within the Re(I) core. Thus, emission can be ascribed to a phosphorescent process with a mixture of a MLCT from the Re(dp) ¿ NHC(p*), LLCT from the imidazolyl/pyridyl to the NHC ligand, and LC (NHC derivative) transitions. In all cases, the emission maximum is blue-shifted in comparison with that observed in the typical diimine-Re(I) systems. Only the heterobimetallic species displayed antiproliferative activity against tumor lung A549 cells, which was increased after irradiation at 405 nm up to nearly 5 times for complexes 4 and 5. A necrotic process seems to be the preferred cell death mechanism. Fluorescence microscopy showed that only heterobimetallic complexes 4 and 5 were suitable for cell visualization. Their biodistribution pattern reveals accumulation within the cytoplasm close to the nucleus and some nucleus permeation. Overall it can be suggested that, whereas the emissive properties are dominated by the NHC-Re(I) fragment, the anticancer activity is mainly dependent on the Au(I) counterpart.
000084152 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E07-17R$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-70371-REDT$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P
000084152 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000084152 590__ $$a4.1$$b2018
000084152 591__ $$aCHEMISTRY, ORGANIC$$b11 / 57 = 0.193$$c2018$$dQ1$$eT1
000084152 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b5 / 45 = 0.111$$c2018$$dQ1$$eT1
000084152 592__ $$a1.473$$b2018
000084152 593__ $$aInorganic Chemistry$$c2018$$dQ1
000084152 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ1
000084152 593__ $$aOrganic Chemistry$$c2018$$dQ1
000084152 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000084152 700__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa
000084152 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000084152 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M.Concepción$$uUniversidad de Zaragoza
000084152 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000084152 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000084152 773__ $$g37, 21 (2018), 3993-4001$$pOrganometallics$$tOrganometallics$$x0276-7333
000084152 8564_ $$s1078839$$uhttps://zaguan.unizar.es/record/84152/files/texto_completo.pdf$$yPostprint
000084152 8564_ $$s3066607$$uhttps://zaguan.unizar.es/record/84152/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000084152 909CO $$ooai:zaguan.unizar.es:84152$$particulos$$pdriver
000084152 951__ $$a2025-01-17-14:44:54
000084152 980__ $$aARTICLE