84152 20250117145308.0 doi 10.1021/acs.organomet.8b00601 sideral 108815 ART-2018-108815 eng Luengo, Andrés Bioactive Heterobimetallic Re(I)/Au(I) Complexes Containing Bidentate N-Heterocyclic Carbenes 2018 Access copy available to the general public Unrestricted The first cationic heterobimetallic complexes of the type fac-[Re(CO)3(NHC)(LAuPPh3)]+, where NHC is an imidazole pyridine-based carbene and L is 3-pyridylalkyne, 4-pyridylalkyne, or 5-ethynyl-1-methyl-1H-imidazole, have been synthesized together with their Re(I) precursors. All of them have showed similar emissive properties resulting from the presence of the NHC system within the Re(I) core. Thus, emission can be ascribed to a phosphorescent process with a mixture of a MLCT from the Re(dp) ¿ NHC(p*), LLCT from the imidazolyl/pyridyl to the NHC ligand, and LC (NHC derivative) transitions. In all cases, the emission maximum is blue-shifted in comparison with that observed in the typical diimine-Re(I) systems. Only the heterobimetallic species displayed antiproliferative activity against tumor lung A549 cells, which was increased after irradiation at 405 nm up to nearly 5 times for complexes 4 and 5. A necrotic process seems to be the preferred cell death mechanism. Fluorescence microscopy showed that only heterobimetallic complexes 4 and 5 were suitable for cell visualization. Their biodistribution pattern reveals accumulation within the cytoplasm close to the nucleus and some nucleus permeation. Overall it can be suggested that, whereas the emissive properties are dominated by the NHC-Re(I) fragment, the anticancer activity is mainly dependent on the Au(I) counterpart. info:eu-repo/grantAgreement/ES/DGA/E07-17R info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-70371-REDT info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.1 2018 CHEMISTRY, ORGANIC 11 / 57 = 0.193 2018 Q1 T1 CHEMISTRY, INORGANIC & NUCLEAR 5 / 45 = 0.111 2018 Q1 T1 1.473 2018 Inorganic Chemistry 2018 Q1 Physical and Theoretical Chemistry 2018 Q1 Organic Chemistry 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Fernández-Moreira, Vanesa (orcid)0000-0002-1218-7218 Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 Gimeno, M.Concepción Universidad de Zaragoza (orcid)0000-0003-0553-0695 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 37, 21 (2018), 3993-4001 Organometallics Organometallics 0276-7333 1078839 http://zaguan.unizar.es/record/84152/files/texto_completo.pdf Postprint 3066607 http://zaguan.unizar.es/record/84152/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84152 articulos driver 2025-01-17-14:44:54 ARTICLE