000084169 001__ 84169 000084169 005__ 20191025173141.0 000084169 0247_ $$2doi$$a10.1088/1478-3975/8/6/066008 000084169 0248_ $$2sideral$$a75186 000084169 037__ $$aART-2011-75186 000084169 041__ $$aeng 000084169 100__ $$0(orcid)0000-0002-3784-1140$$aBorau, C. 000084169 245__ $$aMechano-sensing and cell migration: A 3D model approach 000084169 260__ $$c2011 000084169 5060_ $$aAccess copy available to the general public$$fUnrestricted 000084169 5203_ $$aCell migration is essential for tissue development in different physiological and pathological conditions. It is a complex process orchestrated by chemistry, biological factors, microstructure and surrounding mechanical properties. Focusing on the mechanical interactions, cells do not only exert forces on the matrix that surrounds them, but they also sense and react to mechanical cues in a process called mechano-sensing. Here, we hypothesize the involvement of mechano-sensing in the regulation of directional cell migration through a three-dimensional (3D) matrix. For this purpose, we develop a 3D numerical model of individual cell migration, which incorporates the mechano-sensing process of the cell as the main mechanism regulating its movement. Consistent with this hypothesis, we found that factors, such as substrate stiffness, boundary conditions and external forces, regulate specific and distinct cell movements. 000084169 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BES-2010-029927-FPI$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2009-14115-CO3-01 000084169 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000084169 590__ $$a2.595$$b2011 000084169 591__ $$aBIOPHYSICS$$b36 / 74 = 0.486$$c2011$$dQ2$$eT2 000084169 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000084169 700__ $$aKamm, R. D. 000084169 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, J. M.$$uUniversidad de Zaragoza 000084169 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000084169 773__ $$g8, 6 (2011), [13 pp.]$$pPhys. Biol.$$tPhysical Biology$$x1478-3967 000084169 8564_ $$s1038049$$uhttps://zaguan.unizar.es/record/84169/files/texto_completo.pdf$$yVersión publicada 000084169 8564_ $$s111604$$uhttps://zaguan.unizar.es/record/84169/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000084169 909CO $$ooai:zaguan.unizar.es:84169$$particulos$$pdriver 000084169 951__ $$a2019-10-25-15:00:07 000084169 980__ $$aARTICLE