84169 20191025173141.0 doi 10.1088/1478-3975/8/6/066008 sideral 75186 ART-2011-75186 eng (orcid)0000-0002-3784-1140 Borau, C. Mechano-sensing and cell migration: A 3D model approach 2011 Access copy available to the general public Unrestricted Cell migration is essential for tissue development in different physiological and pathological conditions. It is a complex process orchestrated by chemistry, biological factors, microstructure and surrounding mechanical properties. Focusing on the mechanical interactions, cells do not only exert forces on the matrix that surrounds them, but they also sense and react to mechanical cues in a process called mechano-sensing. Here, we hypothesize the involvement of mechano-sensing in the regulation of directional cell migration through a three-dimensional (3D) matrix. For this purpose, we develop a 3D numerical model of individual cell migration, which incorporates the mechano-sensing process of the cell as the main mechanism regulating its movement. Consistent with this hypothesis, we found that factors, such as substrate stiffness, boundary conditions and external forces, regulate specific and distinct cell movements. info:eu-repo/grantAgreement/ES/MINECO/BES-2010-029927-FPI info:eu-repo/grantAgreement/ES/MINECO/DPI2009-14115-CO3-01 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.595 2011 BIOPHYSICS 36 / 74 = 0.486 2011 Q2 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Kamm, R. D. (orcid)0000-0002-9864-7683 García-Aznar, J. M. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 8, 6 (2011), [13 pp.] Phys. Biol. Physical Biology 1478-3967 1038049 http://zaguan.unizar.es/record/84169/files/texto_completo.pdf Versión publicada 111604 http://zaguan.unizar.es/record/84169/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:84169 articulos driver 2019-10-25-15:00:07 ARTICLE