84192 20200729203742.0 doi 10.1016/j.jtbi.2018.10.034 sideral 108748 ART-2019-108748 eng Karami, M. Assessing the role of Ca2+ in skeletal muscle fatigue using a multi-scale continuum model 2019 Access copy available to the general public Unrestricted The Calcium ion Ca2+ plays a critical role as an initiator and preserving agent of the cross-bridge cycle in the force generation of skeletal muscle. A new multi-scale chemo-mechanical model is presented in order to analyze the role of Ca2+ in muscle fatigue and to predict fatigue behavior. To this end, a cross-bridge kinematic model was incorporated in a continuum based mechanical model, considering a thermodynamic compatible framework. The contractile velocity and the generated active force were directly related to the force-bearing states that were considered for the cross-bridge cycle. In order to determine the values of the model parameters, the output results of an isometric simulation were initially fitted with experimental data obtained for rabbit Extensor Digitorum Longus muscle. Furthermore, a simulated force-velocity curve under concentric contractions was compared with reported experimental results. Finally, by varying the Ca2+ concentration level and its kinetics in the tissue, the model was able to predict the evolution of the active force of an experimental fatigue protocol. The good agreement observed between the simulated results and the experimental outcomes proves the ability of the model to reproduce the fatigue behavior and its applicability for more detailed multidisciplinary investigations related to chemical conditions in muscle performance. info:eu-repo/grantAgreement/ES/DGA/T24-17R info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.327 2019 0.568 2019 MATHEMATICAL & COMPUTATIONAL BIOLOGY 17 / 59 = 0.288 2019 Q2 T1 Agricultural and Biological Sciences (miscellaneous) 2019 Q1 BIOLOGY 39 / 93 = 0.419 2019 Q2 T2 Applied Mathematics 2019 Q2 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2019 Q2 Statistics and Probability 2019 Q2 Medicine (miscellaneous) 2019 Q2 Modeling and Simulation 2019 Q2 Immunology and Microbiology (miscellaneous) 2019 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-9713-1813 Calvo, B. Universidad de Zaragoza Zohoor, H. Firoozbakhsh, K. (orcid)0000-0002-6870-0594 Grasa, J. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 461 (2019), 76-83 J. theor. biol. Journal of Theoretical Biology 0022-5193 748715 http://zaguan.unizar.es/record/84192/files/texto_completo.pdf Postprint 209048 http://zaguan.unizar.es/record/84192/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84192 articulos driver 2020-07-29-20:20:18 ARTICLE