000084199 001__ 84199 000084199 005__ 20200513005822.0 000084199 0247_ $$2doi$$a10.1016/j.neubiorev.2018.09.012 000084199 0248_ $$2sideral$$a108512 000084199 037__ $$aART-2018-108512 000084199 041__ $$aeng 000084199 100__ $$aPorcelli, S. 000084199 245__ $$aSocial brain, social dysfunction and social withdrawal 000084199 260__ $$c2018 000084199 5060_ $$aAccess copy available to the general public$$fUnrestricted 000084199 5203_ $$aThe human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer''s disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions. 000084199 536__ $$9info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115916-PRISM 000084199 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000084199 590__ $$a8.002$$b2018 000084199 591__ $$aNEUROSCIENCES$$b18 / 266 = 0.068$$c2018$$dQ1$$eT1 000084199 591__ $$aBEHAVIORAL SCIENCES$$b3 / 53 = 0.057$$c2018$$dQ1$$eT1 000084199 592__ $$a3.734$$b2018 000084199 593__ $$aBehavioral Neuroscience$$c2018$$dQ1 000084199 593__ $$aNeuropsychology and Physiological Psychology$$c2018$$dQ1 000084199 593__ $$aCognitive Neuroscience$$c2018$$dQ1 000084199 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000084199 700__ $$aVan Der Wee, N. 000084199 700__ $$avan der Werff, S. 000084199 700__ $$aAghajani, M. 000084199 700__ $$aGlennon, J.C. 000084199 700__ $$avan Heukelum, S. 000084199 700__ $$aMogavero, F. 000084199 700__ $$0(orcid)0000-0003-3025-8048$$aLobo, A.$$uUniversidad de Zaragoza 000084199 700__ $$aOlivera, F.J.$$uUniversidad de Zaragoza 000084199 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza 000084199 700__ $$aPosadas, M. 000084199 700__ $$aDukart, J. 000084199 700__ $$aKozak, R. 000084199 700__ $$aArce, E. 000084199 700__ $$aIkram, A. 000084199 700__ $$aVorstman, J. 000084199 700__ $$aBilderbeck, A. 000084199 700__ $$aSaris, I. 000084199 700__ $$aKas, M.J. 000084199 700__ $$aSerretti, A. 000084199 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana 000084199 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000084199 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ. 000084199 773__ $$g97 (2018), 10 - 33$$pNeurosci. biobehav. rev.$$tNEUROSCIENCE AND BIOBEHAVIORAL REVIEWS$$x0149-7634 000084199 8564_ $$s439985$$uhttps://zaguan.unizar.es/record/84199/files/texto_completo.pdf$$yPostprint 000084199 8564_ $$s58943$$uhttps://zaguan.unizar.es/record/84199/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000084199 909CO $$ooai:zaguan.unizar.es:84199$$particulos$$pdriver 000084199 951__ $$a2020-05-13-00:50:13 000084199 980__ $$aARTICLE