84199 20260107185708.0 doi 10.1016/j.neubiorev.2018.09.012 sideral 108512 ART-2018-108512 eng Porcelli, S. Social brain, social dysfunction and social withdrawal 2018 Access copy available to the general public Unrestricted The human social brain is complex. Current knowledge fails to define the neurobiological processes underlying social behaviour involving the (patho-) physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Unfortunately, such a high complexity may also be associated with a high susceptibility to several pathogenic interventions. Consistently, social deficits sometimes represent the first signs of a number of neuropsychiatric disorders including schizophrenia (SCZ), Alzheimer''s disease (AD) and major depressive disorder (MDD) which leads to a progressive social dysfunction. In the present review we summarize present knowledge linking neurobiological substrates sustaining social functioning, social dysfunction and social withdrawal in major psychiatric disorders. Interestingly, AD, SCZ, and MDD affect the social brain in similar ways. Thus, social dysfunction and its most evident clinical expression (i.e., social withdrawal) may represent an innovative transdiagnostic domain, with the potential of being an independent entity in terms of biological roots, with the perspective of targeted interventions. info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115916-PRISM info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 8.002 2018 NEUROSCIENCES 18 / 266 = 0.068 2018 Q1 T1 BEHAVIORAL SCIENCES 3 / 53 = 0.057 2018 Q1 T1 3.734 2018 Behavioral Neuroscience 2018 Q1 Neuropsychology and Physiological Psychology 2018 Q1 Cognitive Neuroscience 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Van Der Wee, N. van der Werff, S. Aghajani, M. Glennon, J.C. van Heukelum, S. Mogavero, F. Lobo, A. Universidad de Zaragoza (orcid)0000-0003-3025-8048 Olivera, F.J. Universidad de Zaragoza (orcid)0000-0001-9243-0339 Lobo, E. Universidad de Zaragoza (orcid)0000-0002-1252-2397 Posadas, M. Dukart, J. Kozak, R. Arce, E. Ikram, A. Vorstman, J. Bilderbeck, A. Saris, I. Kas, M.J. Serretti, A. 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 97 (2018), 10 - 33 Neurosci. biobehav. rev. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 0149-7634 439985 http://zaguan.unizar.es/record/84199/files/texto_completo.pdf Postprint 58943 http://zaguan.unizar.es/record/84199/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84199 articulos driver 2026-01-07-18:55:36 ARTICLE