84204 20200513005822.0 doi 10.1016/j.addr.2018.10.004 sideral 108564 ART-2018-108564 eng (orcid)0000-0002-2861-2469 Moros, M. Universidad de Zaragoza Triggering antitumoural drug release and gene expression by magnetic hyperthermia 2018 Access copy available to the general public Unrestricted Magnetic nanoparticles (MNPs) are promising tools for a wide array of biomedical applications. One of their most outstanding properties is the ability to generate heat when exposed to alternating magnetic fields, usually exploited in magnetic hyperthermia therapy of cancer. In this contribution, we provide a critical review of the use of MNPs and magnetic hyperthermia as drug release and gene expression triggers for cancer therapy. Several strategies for the release of chemotherapeutic drugs from thermo-responsive matrices are discussed, providing representative examples of their application at different levels (from proof of concept to in vivo applications). The potential of magnetic hyperthermia to promote in situ expression of therapeutic genes using vectors that contain heat-responsive promoters is also reviewed in the context of cancer gene therapy. info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512 info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 15.519 2018 PHARMACOLOGY & PHARMACY 3 / 266 = 0.011 2018 Q1 T1 4.163 2018 Pharmaceutical Science 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-3373-9341 Idiago-López, J. (orcid)0000-0003-0641-3407 Asín, L. Universidad de Zaragoza (orcid)0000-0002-8223-3267 Moreno-Antolín, E. (orcid)0000-0003-4516-8694 Beola, L. (orcid)0000-0001-6170-4237 Grazú, V. Universidad de Zaragoza (orcid)0000-0001-5559-8757 Fratila, R.M. (orcid)0000-0003-2366-3598 Gutiérrez, L. Universidad de Zaragoza (orcid)0000-0003-1081-8482 de la Fuente, J.M. Universidad de Zaragoza 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 138 (2018), 326 - 343 Adv. drug deliv. rev. ADVANCED DRUG DELIVERY REVIEWS 0169-409X 703154 http://zaguan.unizar.es/record/84204/files/texto_completo.pdf Postprint 38826 http://zaguan.unizar.es/record/84204/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84204 articulos driver 2020-05-13-00:50:21 ARTICLE