000084219 001__ 84219
000084219 005__ 20250425133128.0
000084219 0247_ $$2doi$$a10.1089/ars.2017.7442
000084219 0248_ $$2sideral$$a107910
000084219 037__ $$aART-2019-107910
000084219 041__ $$aeng
000084219 100__ $$0(orcid)0000-0001-6435-3540$$aSevilla, Emma$$uUniversidad de Zaragoza
000084219 245__ $$aRedox-based transcriptional regulation in prokaryotes: revisiting model mechanisms
000084219 260__ $$c2019
000084219 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084219 5203_ $$aSignificance: The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through diverse mechanisms. Recent Advances: This comprehensive review focuses on the main mechanisms used by major redox-responsive regulators in prokaryotes and their relationship with the different redox signals received by the cell. An overview of the corresponding regulons is also provided. Critical Issues: Some regulators are difficult to classify since they may contain several sensing domains and respond to more than one signal. We propose a classification of redox-sensing regulators into three major groups. The first group contains one-component or direct regulators, whose sensing and regulatory domains are in the same protein. The second group comprises the classical two-component systems involving a sensor kinase that transduces the redox signal to its DNA-binding partner. The third group encompasses a heterogeneous group of flavin-based photosensors whose mechanisms are not always fully understood and are often involved in more complex regulatory networks. Future Directions: Redox-responsive transcriptional regulation is an intricate process as identical signals may be sensed and transduced by different transcription factors, which often interplay with other DNA-binding proteins with or without regulatory activity. Although there is much information about some key regulators, many others remain to be fully characterized due to the instability of their clusters under oxygen. Understanding the mechanisms and the regulatory networks operated by these regulators is essential for the development of future applications in biotechnology and medicine.
000084219 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B18$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2016-77671-P
000084219 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000084219 590__ $$a7.04$$b2019
000084219 591__ $$aENDOCRINOLOGY & METABOLISM$$b13 / 143 = 0.091$$c2019$$dQ1$$eT1
000084219 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b35 / 296 = 0.118$$c2019$$dQ1$$eT1
000084219 592__ $$a2.163$$b2019
000084219 593__ $$aBiochemistry$$c2019$$dQ1
000084219 593__ $$aCell Biology$$c2019$$dQ1
000084219 593__ $$aPhysiology$$c2019$$dQ1
000084219 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000084219 593__ $$aMolecular Biology$$c2019$$dQ1
000084219 593__ $$aClinical Biochemistry$$c2019$$dQ1
000084219 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000084219 700__ $$0(orcid)0000-0002-8181-2689$$aBes, M. Teresa$$uUniversidad de Zaragoza
000084219 700__ $$0(orcid)0000-0002-0531-0943$$aGonzález Rodríguez, Andrés$$uUniversidad de Zaragoza
000084219 700__ $$0(orcid)0000-0002-2742-3711$$aPeleato, M. Luisa$$uUniversidad de Zaragoza
000084219 700__ $$0(orcid)0000-0001-8644-4574$$aFillat, María F.$$uUniversidad de Zaragoza
000084219 7102_ $$11002$$2412$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Fisiología Vegetal
000084219 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000084219 773__ $$g30, 13 (2019), 1651-1696$$pAntioxid. redox signal.$$tAntioxidants & redox signaling$$x1523-0864
000084219 8564_ $$s1886316$$uhttps://zaguan.unizar.es/record/84219/files/texto_completo.pdf$$yVersión publicada
000084219 8564_ $$s2158588$$uhttps://zaguan.unizar.es/record/84219/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000084219 909CO $$ooai:zaguan.unizar.es:84219$$particulos$$pdriver
000084219 951__ $$a2025-04-25-13:29:45
000084219 980__ $$aARTICLE