84321 20201105083209.0 doi 10.1016/j.neubiorev.2018.09.025 sideral 109568 ART-2018-109568 eng Gilmour, G. Relating constructs of attention and working memory to social withdrawal in Alzheimer's disease and schizophrenia: issues regarding paradigm selection 2018 Access copy available to the general public Unrestricted Central nervous system diseases are not currently diagnosed based on knowledge of biological mechanisms underlying their symptoms. Greater understanding may be offered through an agnostic approach to traditional disease categories, where learning more about shared biological mechanisms across conditions could potentially reclassify sub-groups of patients to allow realisation of more effective treatments. This review represents the output of the collaborative group “PRISM”, tasked with considering assay choices for assessment of attention and working memory in a transdiagnostic cohort of Alzheimer''s disease and schizophrenia patients exhibiting symptomatic spectra of social withdrawal. A multidimensional analysis of this nature has not been previously attempted. Nominated assays (continuous performance test III, attention network test, digit symbol substitution, N-back, complex span, spatial navigation in a virtual environment) reflected a necessary compromise between the need for broad assessment of the neuropsychological constructs in question with several pragmatic criteria: patient burden, compatibility with neurophysiologic measures and availability of preclinical homologues. info:eu-repo/grantAgreement/EC/H2020/115916/EU/Psychiatric Ratings using Intermediate Stratified Markers/PRISM This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115916-PRISM info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 8.002 2018 NEUROSCIENCES 18 / 266 = 0.068 2018 Q1 T1 BEHAVIORAL SCIENCES 3 / 53 = 0.057 2018 Q1 T1 3.734 2018 Behavioral Neuroscience 2018 Q1 Neuropsychology and Physiological Psychology 2018 Q1 Cognitive Neuroscience 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Porcelli, S. Bertaina-Anglade, V. Arce, E. Dukart, J. Hayen, A. (orcid)0000-0003-3025-8048 Lobo, A. Universidad de Zaragoza (orcid)0000-0002-3360-7015 Lopez-Anton, R. Universidad de Zaragoza Merlo Pich, E. Pemberton, D.J. Havenith, M.N. Glennon, J.C. Harel, B.T. Dawson, G. Marston, H. Kozak, R. Serretti, A. 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 97 (2018), 47-69 Neurosci. biobehav. rev. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 0149-7634 870551 http://zaguan.unizar.es/record/84321/files/texto_completo.pdf Postprint 59712 http://zaguan.unizar.es/record/84321/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84321 articulos driver 2020-11-05-08:20:34 ARTICLE