000084348 001__ 84348 000084348 005__ 20250522134650.0 000084348 0247_ $$2doi$$a10.1038/s41598-019-47283-5 000084348 0248_ $$2sideral$$a113027 000084348 037__ $$aART-2019-113027 000084348 041__ $$aeng 000084348 100__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar$$uUniversidad de Zaragoza 000084348 245__ $$aGenetic predictors of weight loss in overweight and obese subjects 000084348 260__ $$c2019 000084348 5060_ $$aAccess copy available to the general public$$fUnrestricted 000084348 5203_ $$aThe aim of our study was to investigate a large cohort of overweight subjects consuming a homogeneous diet to identify the genetic factors associated with weight loss that could be used as predictive markers in weight loss interventions. We retrospectively recruited subjects (N = 788) aged over 18 years with a Body Mass Index (BMI) between 25 and 40 kg/m(2) who were treated at our lipid unit for at least one year from 2008 to 2016, and we also recruited a control group (168 patients) with normal BMIs. All participants received counselling from a nutritionist that included healthy diet and physical activity recommendations. We genotyped 25 single nucleotide variants (SNVs) in 25 genes that were previously associated with obesity and calculated genetic scores that were derived from 25 SNVs. The risk allele in CADM2 showed a higher frequency in overweight and obese subjects than in controls (p = 0.007). The mean follow-up duration was 5.58 +/- 2.68 years. Subjects with lower genetic scores showed greater weight loss during the follow-up period. The genetic score was the variable that best explained the variations in weight from the baseline. The genetic score explained 2.4% of weight change variance at one year and 1.6% of weight change variance at the end of the follow-up period after adjusting for baseline weight, sex, age and years of follow-up. 000084348 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-01321$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983 000084348 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000084348 590__ $$a3.998$$b2019 000084348 591__ $$aMULTIDISCIPLINARY SCIENCES$$b16 / 70 = 0.229$$c2019$$dQ1$$eT1 000084348 592__ $$a1.341$$b2019 000084348 593__ $$aMultidisciplinary$$c2019$$dQ1 000084348 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000084348 700__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocío$$uUniversidad de Zaragoza 000084348 700__ $$aBea, Ana M. 000084348 700__ $$0(orcid)0009-0008-7807-0400$$aDehesa-Garcia, Blanca 000084348 700__ $$0(orcid)0000-0002-1894-1621$$aPerez-Calahorra, Sofía$$uUniversidad de Zaragoza 000084348 700__ $$aMarco-Benedi, Victoria 000084348 700__ $$aBaila-Rueda, Lucía 000084348 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín 000084348 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza 000084348 700__ $$aCenarro, Ana 000084348 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000084348 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana 000084348 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000084348 773__ $$g9 (2019), 10770 [9 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322 000084348 8564_ $$s1167085$$uhttps://zaguan.unizar.es/record/84348/files/texto_completo.pdf$$yVersión publicada 000084348 8564_ $$s118208$$uhttps://zaguan.unizar.es/record/84348/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000084348 909CO $$ooai:zaguan.unizar.es:84348$$particulos$$pdriver 000084348 951__ $$a2025-05-22-13:45:17 000084348 980__ $$aARTICLE