000084349 001__ 84349 000084349 005__ 20200716101522.0 000084349 0247_ $$2doi$$a10.3389/fimmu.2019.01730 000084349 0248_ $$2sideral$$a113032 000084349 037__ $$aART-2019-113032 000084349 041__ $$aeng 000084349 100__ $$aGarmendia, Junkal 000084349 245__ $$aUpdate on the Immune Mechanisms Against Respiratory Pathogens 000084349 260__ $$c2019 000084349 5060_ $$aAccess copy available to the general public$$fUnrestricted 000084349 5203_ $$aRespiratory infections pose a continuous threat to humans due to their easy dissemination via aerial transmission. As a consequence, they are leading causes of mortality and morbidity worldwide. Lower respiratory tract infections (LRTI) remained the deadliest communicable diseases causing 3 million deaths worldwide in 2016 (1). Similarly, although the number of tuberculosis (TB) deaths tends to decrease, it is still among the top 10 causes of global mortality with a yearly death burden of about 1.6 million (2). The growing emergence of bacterial antibiotic resistance is a major global challenge for the coming years, and several major respiratory pathogens are included in the WHO priority list of bacteria for which new antibiotics are urgently needed (3). In terms of target population, children under the age of five are the most susceptible hosts to a plethora of respiratory pathogens. 000084349 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BFU2015-72190-EXP$$9info:eu-repo/grantAgreement/ES/MINECO/RTI2018-096369-B-I00$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2015-66520-R 000084349 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000084349 590__ $$a5.085$$b2019 000084349 591__ $$aIMMUNOLOGY$$b38 / 158 = 0.241$$c2019$$dQ1$$eT1 000084349 592__ $$a2.116$$b2019 000084349 593__ $$aImmunology and Allergy$$c2019$$dQ1 000084349 593__ $$aImmunology$$c2019$$dQ1 000084349 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion 000084349 700__ $$0(orcid)0000-0001-8841-6593$$aGonzalo-Asensio, Jesús$$uUniversidad de Zaragoza 000084349 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología 000084349 773__ $$g10 (2019), 1730 [4 pp.]$$pFront. immunol.$$tFRONTIERS IN IMMUNOLOGY$$x1664-3224 000084349 8564_ $$s236575$$uhttps://zaguan.unizar.es/record/84349/files/texto_completo.pdf$$yVersión publicada 000084349 8564_ $$s11242$$uhttps://zaguan.unizar.es/record/84349/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000084349 909CO $$ooai:zaguan.unizar.es:84349$$particulos$$pdriver 000084349 951__ $$a2020-07-16-09:27:32 000084349 980__ $$aARTICLE