84378 20201019094020.0 doi 10.3390/nu11092253 sideral 113999 ART-2019-113999 eng Del Olmo, Nuria Differential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors 2019 Access copy available to the general public Unrestricted BACKGROUND: Dietary factors have significant effects on the brain, modulating mood, anxiety, motivation and cognition. To date, no attention has been paid to the consequences that the combination of ethanol (EtOH) and a high-fat diet (HFD) have on learning and mood disorders during adolescence. The aim of the present work was to evaluate the biochemical and behavioral consequences of ethanol binge drinking and an HFD consumption in adolescent mice. METHODS: Animals received either a standard diet or an HFD (ad libitum vs. binge pattern) in combination with ethanol binge drinking and were evaluated in anxiety and memory. The metabolic profile and gene expression of leptin receptors and clock genes were also evaluated. RESULTS: Excessive white adipose tissue and an increase in plasma insulin and leptin levels were mainly observed in ad libitum HFD + EtOH mice. An upregulation of the Lepr gene expression in the prefrontal cortex and the hippocampus was also observed in ad libitum HFD groups. EtOH-induced impairment on spatial memory retrieval was absent in mice exposed to an HFD, although the aversive memory deficits persisted. Mice bingeing on an HFD only showed an anxiolytic profile, without other alterations. We also observed a mismatch between Clock and Bmal1 expression in ad libitum HFD animals, which were mostly independent of EtOH bingeing. CONCLUSIONS: Our results confirm the bidirectional influence that occurs between the composition and intake pattern of a HFD and ethanol consumption during adolescence, even when the metabolic, behavioral and chronobiological effects of this interaction are dissociated. info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0005 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007 info:eu-repo/grantAgreement/ES/MINECO/BFU2016-68556-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.546 2019 NUTRITION & DIETETICS 17 / 89 = 0.191 2019 Q1 T1 1.329 2019 Nutrition and Dietetics 2019 Q1 Food Science 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-5990-1266 Blanco-Gandía, M.Carmen Universidad de Zaragoza Mateos-García, Ana Del Rio, Danila Miñarro, José Ruiz-Gayo, Mariano Rodríguez-Arias, Marta 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 11, 9 (2019), 2253 [18 pp.] NUTRIENTS Nutrients 2072-6643 1119480 http://zaguan.unizar.es/record/84378/files/texto_completo.pdf Versión publicada 103564 http://zaguan.unizar.es/record/84378/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:84378 articulos driver 2020-10-19-09:35:51 ARTICLE