000084677 001__ 84677 000084677 005__ 20210204133439.0 000084677 0247_ $$2doi$$a10.1111/tri.13372 000084677 0248_ $$2sideral$$a109804 000084677 037__ $$aART-2018-109804 000084677 041__ $$aeng 000084677 100__ $$aPuig-Gay, N. 000084677 245__ $$aApolipoprotein A-Ib as a biomarker of focal segmental glomerulosclerosis recurrence after kidney transplantation: diagnostic performance and assessment of its prognostic value – a multi-centre cohort study 000084677 260__ $$c2018 000084677 5060_ $$aAccess copy available to the general public$$fUnrestricted 000084677 5203_ $$aRecurrence of idiopathic focal segmental glomerulosclerosis (FSGS) is a serious complication after kidney transplantation. FSGS relapse is suspected by a sudden increase in proteinuria but there is not an accurate noninvasive diagnostic tool to confirm this entity or to detect patients at risk. We aimed to validate the diagnostic performance of ApoA-Ib to detect FSGS relapses by measuring urinary ApoA-Ib in a retrospective cohort of 61 kidney transplanted patients (37 FSGS and 24 non-FSGS). In addition, to assess the ApoA-Ib predictive ability, ApoA-Ib was measured periodically in a prospective cohort of 13 idiopathic FSGS patients who were followed during 1 year after transplantation. ApoA-Ib had a sensitivity of 93.3% and a specificity of 90.9% to diagnose FSGS relapses, with a high negative predictive value (95.2%), confirming our previous results. In the prospective cohort, ApoA-Ib predated the recurrence in four of five episodes observed. In the nonrelapsing group (n = 9), ApoA-Ib was negative in 37 of 38 samples. ApoA-Ib has the potential to be a good diagnostic biomarker of FSGS relapses, providing a confident criterion to exclude false positives even in the presence of high proteinuria. It has also the potential to detect patients at risk of relapse, even before transplantation. 000084677 536__ $$9info:eu-repo/grantAgreement/ES/FIS-FEDER/PI14-00275$$9info:eu-repo/grantAgreement/ES/ISCIII/REDINREN-RD120021-0013$$9info:eu-repo/grantAgreement/ES/ISCIII/REDINREN-RD16-0009-0006 000084677 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000084677 590__ $$a3.526$$b2018 000084677 591__ $$aSURGERY$$b31 / 203 = 0.153$$c2018$$dQ1$$eT1 000084677 591__ $$aTRANSPLANTATION$$b8 / 25 = 0.32$$c2018$$dQ2$$eT1 000084677 592__ $$a1.296$$b2018 000084677 593__ $$aTransplantation$$c2018$$dQ1 000084677 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000084677 700__ $$aJacobs-Cacha, C. 000084677 700__ $$aSellarès, J. 000084677 700__ $$aGuirado, L. 000084677 700__ $$aGonzález Roncero, F. 000084677 700__ $$aJiménez, C. 000084677 700__ $$aZárraga, S. 000084677 700__ $$0(orcid)0000-0002-0175-3739$$aPaul, J.$$uUniversidad de Zaragoza 000084677 700__ $$aLauzurica, R. 000084677 700__ $$aAlonso, Á. 000084677 700__ $$aFernández, A. 000084677 700__ $$aBeneyto, I. 000084677 700__ $$aMazuecos, A. 000084677 700__ $$aHernández, D. 000084677 700__ $$aRodriguez-Benot, A. 000084677 700__ $$aFranco, A. 000084677 700__ $$aJimeno, L. 000084677 700__ $$aCrespo, M. 000084677 700__ $$aMeseguer, A. 000084677 700__ $$aMoreso, F. 000084677 700__ $$aSeron, D. 000084677 700__ $$aLopez-Hellin, J. 000084677 700__ $$aCantarell, C. 000084677 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000084677 773__ $$g32, 3 (2018), 313 - 322$$pTranspl. int.$$tTRANSPLANT INTERNATIONAL$$x0934-0874 000084677 8564_ $$s247926$$uhttps://zaguan.unizar.es/record/84677/files/texto_completo.pdf$$yPostprint 000084677 8564_ $$s78049$$uhttps://zaguan.unizar.es/record/84677/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000084677 909CO $$ooai:zaguan.unizar.es:84677$$particulos$$pdriver 000084677 951__ $$a2021-02-04-13:33:34 000084677 980__ $$aARTICLE