84692 20200513005826.0 doi 10.1007/s10620-018-5362-3 sideral 109098 ART-2018-109098 eng Chaparro, M. Correlation Between Anti-TNF Serum Levels and Endoscopic Inflammation in Inflammatory Bowel Disease Patients 2018 Access copy available to the general public Unrestricted Objectives: (a) To evaluate the diagnostic accuracy of anti-TNF trough levels to predict mucosal healing in inflammatory bowel disease (IBD); (b) to determine the best cut-off point to predict mucosal healing in IBD patients treated with anti-TNF. Methods: This is a multicenter, prospective study. IBD patients under anti-TNF treatment for at least 6 months that had to undergo an endoscopy were included. Mucosal healing was defined as: Simple endoscopic score for Crohn’s Disease < 3 for Crohn’s disease (CD), Rutgeerts score < i2 for CD in postoperative setting, or Mayo endoscopic score = 1 for ulcerative colitis (UC). Anti-TNF concentrations were measured using SMART ELISAs at trough. Results: A total of 182 patients were included. Anti-TNF trough levels were significantly higher among patients that had mucosal healing than among those who did not. The area under the curve of infliximab for mucosal healing was 0.63 (best cutoff value 3.4 µg/mL), and for adalimumab 0.60 (best cutoff value 7.2 µg/mL). In the multivariate analysis, having anti-TNF drug levels above the cutoff values [odds ratio (OR) 3.1]) and having UC instead of CD (OR 4) were associated with a higher probability of having mucosal healing. Additionally, the need for an escalated dosage (OR 0.2) and current smoking habit (OR 0.2) were also associated with a lower probability of mucosal healing. Conclusions: There was an association between anti-TNF trough levels and mucosal healing in IBD patients; however, the accuracy of the determination of infliximab and adalimumab concentrations able to predict mucosal healing was suboptimal. info:eu-repo/grantAgreement/ES/ISCIII/FIS/12-02557 info:eu-repo/grantAgreement/ES/ISCIII/PI13-00041 info:eu-repo/grantAgreement/ES/MINECO/SAF2014-56642-JIN info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.937 2018 GASTROENTEROLOGY & HEPATOLOGY 48 / 84 = 0.571 2018 Q3 T2 1.292 2018 Physiology 2018 Q1 Gastroenterology 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Barreiro-de Acosta, M. Echarri, A. Almendros, R. Barrio, J. Llao, J. (orcid)0000-0003-0076-3529 Gomollón, F. Universidad de Zaragoza Vera, M. Cabriada, J.L. Guardiola, J. Guerra, I. Beltrán, B. Roncero, O. Busquets, D. Taxonera, C. Calvet, X. Ferreiro-Iglesias, R. Ollero Pena, V. Bernardo, D. Donday, M.G. Garre, A. Godino, A. Díaz, A. Gisbert, J.P. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 64, 846 - 854 (2018), 1-9 Dig. dis. sci. DIGESTIVE DISEASES AND SCIENCES 0163-2116 601771 http://zaguan.unizar.es/record/84692/files/texto_completo.pdf Postprint 26775 http://zaguan.unizar.es/record/84692/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:84692 articulos driver 2020-05-13-00:51:58 ARTICLE