84715 20250619084223.0 doi 10.1063/1.5099038 sideral 114032 ART-2019-114032 eng Faci-Lázaro, Sergio Universidad de Zaragoza Impact of targeted attack on the spontaneous activity in spatial and biologically-inspired neuronal networks 2019 Access copy available to the general public Unrestricted We study the structural and dynamical consequences of damage in spatial neuronal networks. Inspired by real in vitro networks, we construct directed networks embedded in a two-dimensional space and follow biological rules for designing the wiring of the system. As a result, synthetic cultures display strong metric correlations similar to those observed in real experiments. In its turn, neuronal dynamics is incorporated through the Izhikevich model adopting the parameters derived from observation in real cultures. We consider two scenarios for damage, targeted attacks on those neurons with the highest out-degree and random failures. By analyzing the evolution of both the giant connected component and the dynamical patterns of the neurons as nodes are removed, we observe that network activity halts for a removal of 50% of the nodes in targeted attacks, much lower than the 70% node removal required in the case of random failures. Notably, the decrease of neuronal activity is not gradual. Both damage scenarios portray "boosts" of activity just before full silencing that are not present in equivalent random (Erdös-Rényi) graphs. These boosts correspond to small, spatially compact subnetworks that are able to maintain high levels of activity. Since these subnetworks are absent in the equivalent random graphs, we hypothesize that metric correlations facilitate the existence of local circuits sufficiently integrated to maintain activity, shaping an intrinsic mechanism for resilience. info:eu-repo/grantAgreement/ES/DGA/FENOL-GROUP info:eu-repo/grantAgreement/ES/MINECO/FIS2015-71582-C2 info:eu-repo/grantAgreement/ES/MINECO/FIS2016-78507-C2-2-P info:eu-repo/grantAgreement/ES/MINECO/FIS2017-87519-P info:eu-repo/grantAgreement/ES/MINECO/FIS2017-90782-REDT info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.832 2019 PHYSICS, MATHEMATICAL 5 / 55 = 0.091 2019 Q1 T1 MATHEMATICS, APPLIED 16 / 260 = 0.062 2019 Q1 T1 0.934 2019 Medicine (miscellaneous) 2019 Q1 Mathematical Physics 2019 Q1 Statistical and Nonlinear Physics 2019 Q1 Physics and Astronomy (miscellaneous) 2019 Q1 Applied Mathematics 2019 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Soriano, Jordi Gómez-Gardeñes, Jesús Universidad de Zaragoza (orcid)0000-0001-5204-1937 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 29, 8 (2019), 083126 1-11 Chaos CHAOS 1054-1500 2667405 http://zaguan.unizar.es/record/84715/files/texto_completo.pdf Versión publicada 29226 http://zaguan.unizar.es/record/84715/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:84715 articulos driver 2025-06-19-08:41:25 ARTICLE