000084736 001__ 84736
000084736 005__ 20230914083239.0
000084736 0247_ $$2doi$$a10.7717/peerj.7797
000084736 0248_ $$2sideral$$a113729
000084736 037__ $$aART-2019-113729
000084736 041__ $$aeng
000084736 100__ $$0(orcid)0000-0001-8537-0585$$aLopez-Minguez, Sandra$$uUniversidad de Zaragoza
000084736 245__ $$aNew tracheal stainless steel stent pilot study: twelve month follow-up in a rabbit model
000084736 260__ $$c2019
000084736 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084736 5203_ $$aBackground
Canine tracheal collapse is a complex airway pathology without promising treatment results. Currently nitinol stents are the best surgical option; however, some professionals are doubting if stent placement is the best option due to the associated complications.
Objective
Determine the technical feasibility, safety, and long-term follow-up after the implantation of a new tracheal stent designed for canine tracheal collapse.
Methods
Thirteen healthy, adult female New Zealander rabbits were involved in this pilot study.A new intra-tracheal device (Reference number 902711 patent registered as CasMin-Twine) was implanted in ten animals. Deployment was performed under general anesthesia, making a puncture incision via a 21 Gauge needle in the intra-tracheal space where the stent was introduced with a screwing process. The device was fixed to the tracheal wall with a non-absorbable suture. Computerized Tomography (CT) and an endoscopy to study structural abnormalities were performed after 30, 90 and 365 days after stent placement.
Results
Technical and clinical success was 100%. There was no significant change in behavior or respiratory disorders. CT studies showed no significant alterations. After the 30 days, 60% of the animals showed partial endothelization in the endoscopy study, and only one animal still presented partial endothelization after 12 months. Mucus accumulation was only present in 40% of cases and classified as low, without respiratory consequences. Only one animal presented a single granuloma at caudal stent tip.
Conclusions
This new tracheal stent (CasMin-Twine) is an effective and safe procedure with promising results, and also shows the possibility of removing the device after endothelization has been produced. New studies should be carried out to evaluate the effectiveness in patients with tracheomalacia.
Clinical Significance/Impact
This new product can give veterinarians a new option of treatment for this complicated pathology. Minimizing specific equipment for its deployment, CasMin-Twine will be more accessible for all professionals.
000084736 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B36-17R
000084736 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000084736 590__ $$a2.379$$b2019
000084736 591__ $$aMULTIDISCIPLINARY SCIENCES$$b32 / 71 = 0.451$$c2019$$dQ2$$eT2
000084736 592__ $$a0.995$$b2019
000084736 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000084736 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2019$$dQ1
000084736 593__ $$aNeuroscience (miscellaneous)$$c2019$$dQ2
000084736 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2019$$dQ2
000084736 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000084736 700__ $$0(orcid)0000-0002-8880-6580$$aSerrano-Casorran, Carolina$$uUniversidad de Zaragoza
000084736 700__ $$0(orcid)0000-0002-0113-5121$$aGuirola, Jose Andres$$uUniversidad de Zaragoza
000084736 700__ $$0(orcid)0000-0003-3880-3821$$aRodriguez-Zapater, Sergio$$uUniversidad de Zaragoza
000084736 700__ $$0(orcid)0000-0001-6178-9891$$aBonastre, Cristina$$uUniversidad de Zaragoza
000084736 700__ $$0(orcid)0000-0002-5618-7519$$aDe Gregorio, Miguel A.$$uUniversidad de Zaragoza
000084736 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física
000084736 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000084736 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000084736 773__ $$g8, 7 (2019), 7797 [14 pp.]$$pPeerJ$$tPeerJ$$x2167-8359
000084736 8564_ $$s6880757$$uhttps://zaguan.unizar.es/record/84736/files/texto_completo.pdf$$yVersión publicada
000084736 8564_ $$s98729$$uhttps://zaguan.unizar.es/record/84736/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000084736 909CO $$ooai:zaguan.unizar.es:84736$$particulos$$pdriver
000084736 951__ $$a2023-09-13-10:47:25
000084736 980__ $$aARTICLE