000084747 001__ 84747
000084747 005__ 20191113143206.0
000084747 0247_ $$2doi$$a10.1155/2019/3567813
000084747 0248_ $$2sideral$$a114095
000084747 037__ $$aART-2019-114095
000084747 041__ $$aeng
000084747 100__ $$aBartol-Puyal, Francisco de Asís
000084747 245__ $$aDistribution of Choroidal Thinning in High Myopia, Diabetes Mellitus, and Aging: A Swept-Source OCT Study
000084747 260__ $$c2019
000084747 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084747 5203_ $$aPurpose. To compare the macular choroidal thinning between young healthy, aged healthy, young high myopic, and aged type 2 diabetic (T2D) patients using the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and three-dimensional (3D) maps. Methods. A prospective study including 102 eyes of 51 healthy young subjects, 60 eyes of 30 healthy aged subjects, 24 eyes of 12 high myopic patients, and 110 eyes of 55 T2D patients. Choroidal thickness (CT) was examined with swept-source optical coherence tomography Triton DRI (Topcon Corporation, Tokyo, Japan). The choroid was automatically segmented using the software algorithm, and mean CT values of a 6 × 6 mm macular cube were exported. 3D maps were created to represent CT, and its values were compared using the ETDRS grid. Results. Mean age was 27.31 ± 3.95, 66.41 ± 7.54, 27.69 ± 3.89, and 66.48 ± 7.59 years in young healthy, aged healthy, young high myopic, and T2D patients, respectively. CT was not shown to be uniform, as superior and central zones were thicker. All ETDRS sectors were always thicker (p<0.05) in young healthy individuals than in the others. It was found that the choroidal sector which got thinner was inferior in case of age (103.28 µm decrease), inferior-nasal in high myopia (86.19 µm decrease), and temporal in T2D (55.57 µm decrease). In addition, the choroid got thinner in those regions where it was thicker in healthy subjects. Conclusions. 3D maps allow a further comprehension of choroidal changes. The choroidal pattern in young healthy individuals resembles a mountain range; with age, a mountain peak; in high myopia, an inverted gorge; and in aged T2D, gathered hills. Not all choroidal regions are affected in a similar way, as it depends on the pathology. The thicker the zone is in healthy subjects, the thinner it becomes with any pathology.
000084747 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000084747 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000084747 700__ $$aIsanta, Carlos
000084747 700__ $$0(orcid)0000-0001-6664-6275$$aRuiz-Moreno, Óscar$$uUniversidad de Zaragoza
000084747 700__ $$aAbadia, Beatriz$$uUniversidad de Zaragoza
000084747 700__ $$0(orcid)0000-0002-6202-2382$$aCalvo, Pilar
000084747 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, Luis$$uUniversidad de Zaragoza
000084747 700__ $$a
000084747 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000084747 773__ $$g2019 (2019), 3567813 [9 pp.]$$pJ. Ophthalmol.$$tJournal of Ophthalmology$$x2090-004X
000084747 8564_ $$s3415018$$uhttps://zaguan.unizar.es/record/84747/files/texto_completo.pdf$$yVersión publicada
000084747 8564_ $$s26896$$uhttps://zaguan.unizar.es/record/84747/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000084747 909CO $$ooai:zaguan.unizar.es:84747$$particulos$$pdriver
000084747 951__ $$a2019-11-13-13:42:04
000084747 980__ $$aARTICLE