000086231 001__ 86231 000086231 005__ 20200716101537.0 000086231 0247_ $$2doi$$a10.1038/s41598-019-52260-z 000086231 0248_ $$2sideral$$a114748 000086231 037__ $$aART-2019-114748 000086231 041__ $$aeng 000086231 100__ $$aMontero-Marin, Jesús 000086231 245__ $$aEffects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial 000086231 260__ $$c2019 000086231 5060_ $$aAccess copy available to the general public$$fUnrestricted 000086231 5203_ $$aFibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-a, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-a and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. 000086231 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B17-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/CD16-00147$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO-FEDER/RD16-0007-0005$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0007-0012$$9info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017 000086231 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000086231 590__ $$a3.998$$b2019 000086231 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 71 = 0.239$$c2019$$dQ1$$eT1 000086231 592__ $$a1.341$$b2019 000086231 593__ $$aMultidisciplinary$$c2019$$dQ1 000086231 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000086231 700__ $$aAndrés-Rodríguez, Laura 000086231 700__ $$aTops, Mattie 000086231 700__ $$aLuciano, Juan V. 000086231 700__ $$0(orcid)0000-0003-4842-0453$$aNavarro-Gil, Mayte$$uUniversidad de Zaragoza 000086231 700__ $$aFeliu-Soler, Albert 000086231 700__ $$0(orcid)0000-0002-1690-4130$$aLópez-del-Hoyo, Yolanda$$uUniversidad de Zaragoza 000086231 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, Javier$$uUniversidad de Zaragoza 000086231 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000086231 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000086231 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000086231 773__ $$g9, 1 (2019), 15639 [14 pp.]$$pSci. rep.$$tScientific Reports$$x2045-2322 000086231 85641 $$uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85074277713&doi=10.1038%2fs41598-019-52260-z&partnerID=40&md5=c5194f1c7f1732ffa2b0991e9f8fd9ce$$zTexto completo de la revista 000086231 8564_ $$s1637295$$uhttps://zaguan.unizar.es/record/86231/files/texto_completo.pdf$$yVersión publicada 000086231 8564_ $$s103004$$uhttps://zaguan.unizar.es/record/86231/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000086231 909CO $$ooai:zaguan.unizar.es:86231$$particulos$$pdriver 000086231 951__ $$a2020-07-16-09:38:00 000086231 980__ $$aARTICLE