86231 20200716101537.0 doi 10.1038/s41598-019-52260-z sideral 114748 ART-2019-114748 eng Montero-Marin, Jesús Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial 2019 Access copy available to the general public Unrestricted Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-a, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-a and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. info:eu-repo/grantAgreement/ES/DGA/B17-17R info:eu-repo/grantAgreement/ES/ISCIII/CD16-00147 info:eu-repo/grantAgreement/ES/ISCIII-MINECO-FEDER/RD16-0007-0005 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0007-0012 info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0018-0017 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.998 2019 MULTIDISCIPLINARY SCIENCES 17 / 71 = 0.239 2019 Q1 T1 1.341 2019 Multidisciplinary 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Andrés-Rodríguez, Laura Tops, Mattie Luciano, Juan V. (orcid)0000-0003-4842-0453 Navarro-Gil, Mayte Universidad de Zaragoza Feliu-Soler, Albert (orcid)0000-0002-1690-4130 López-del-Hoyo, Yolanda Universidad de Zaragoza (orcid)0000-0002-3797-4218 Garcia-Campayo, Javier Universidad de Zaragoza 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 9, 1 (2019), 15639 [14 pp.] Sci. rep. Scientific Reports 2045-2322 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074277713&doi=10.1038%2fs41598-019-52260-z&partnerID=40&md5=c5194f1c7f1732ffa2b0991e9f8fd9ce Texto completo de la revista 1637295 http://zaguan.unizar.es/record/86231/files/texto_completo.pdf Versión publicada 103004 http://zaguan.unizar.es/record/86231/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:86231 articulos driver 2020-07-16-09:38:00 ARTICLE