000086321 001__ 86321 000086321 005__ 20200716101532.0 000086321 0247_ $$2doi$$a10.3390/molecules24162909 000086321 0248_ $$2sideral$$a114975 000086321 037__ $$aART-2019-114975 000086321 041__ $$aeng 000086321 100__ $$aMaiuolo L. 000086321 245__ $$aSynthesis, biological and in silico evaluation of pure nucleobase-containing spiro (Indane-Isoxazolidine) derivatives as potential inhibitors of MDM2-p53 interaction 000086321 260__ $$c2019 000086321 5060_ $$aAccess copy available to the general public$$fUnrestricted 000086321 5203_ $$aNucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1, 3-dipolar cycloaddition starting from indanyl nitrones and N-vinylnucleobases by using environmentally benign microwave technology. The contemporary presence of various structural groups that are individually active scaffolds of different typology of drugs, has directed us to speculate that these compounds may act as inhibitors of MDM2-p53 interaction. Therefore, both computational calculations and antiproliferative screening against A549 human lung adenocarcinoma cells and human SH-SY5Y neuroblastoma cells were carried out to support this hypothesis. 000086321 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E34-R17$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-76155-R 000086321 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000086321 590__ $$a3.267$$b2019 000086321 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b70 / 177 = 0.395$$c2019$$dQ2$$eT2 000086321 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b141 / 297 = 0.475$$c2019$$dQ2$$eT2 000086321 592__ $$a0.698$$b2019 000086321 593__ $$aPharmaceutical Science$$c2019$$dQ1 000086321 593__ $$aChemistry (miscellaneous)$$c2019$$dQ2 000086321 593__ $$aDrug Discovery$$c2019$$dQ2 000086321 593__ $$aPhysical and Theoretical Chemistry$$c2019$$dQ2 000086321 593__ $$aOrganic Chemistry$$c2019$$dQ2 000086321 593__ $$aAnalytical Chemistry$$c2019$$dQ2 000086321 593__ $$aMedicine (miscellaneous)$$c2019$$dQ2 000086321 593__ $$aMolecular Medicine$$c2019$$dQ3 000086321 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000086321 700__ $$aAlgieri V. 000086321 700__ $$aRusso B. 000086321 700__ $$aTallarida M.A. 000086321 700__ $$aNardi M. 000086321 700__ $$aGioia M.L.D. 000086321 700__ $$aMerchant Z. 000086321 700__ $$0(orcid)0000-0002-2202-3460$$aMerino P.$$uUniversidad de Zaragoza 000086321 700__ $$0(orcid)0000-0001-8355-2289$$aDelso I.$$uUniversidad de Zaragoza 000086321 700__ $$aNino A.D. 000086321 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000086321 773__ $$g24, 16 (2019), 2909 [14 pp.]$$pMolecules$$tMolecules$$x1420-3049 000086321 8564_ $$s873716$$uhttps://zaguan.unizar.es/record/86321/files/texto_completo.pdf$$yVersión publicada 000086321 8564_ $$s97588$$uhttps://zaguan.unizar.es/record/86321/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000086321 909CO $$ooai:zaguan.unizar.es:86321$$particulos$$pdriver 000086321 951__ $$a2020-07-16-09:34:45 000086321 980__ $$aARTICLE