000086375 001__ 86375 000086375 005__ 20200716101558.0 000086375 0247_ $$2doi$$a10.1002/acm2.12657 000086375 0248_ $$2sideral$$a115042 000086375 037__ $$aART-2019-115042 000086375 041__ $$aeng 000086375 100__ $$aLozares-Cordero, Sergio 000086375 245__ $$aTreatment of cervical cancer with electronic brachytherapy 000086375 260__ $$c2019 000086375 5060_ $$aAccess copy available to the general public$$fUnrestricted 000086375 5203_ $$aPurpose: We report the first cervical cancer cases treated with interstitial electronic brachytherapy (eBT) at our hospital and compare them with plans made with high-dose-rate interstitial brachytherapy based on Ir192 (HDR-BT). Materials and methods: Eight patients with cervical cancer were treated with the Axxent eBT device (Xoft, Inc.). Planning was with magnetic resonance imaging and computed tomography following the recommendations of the EMBRACE protocol. The dosimetry parameters of organs at risk (OAR) were evaluated for the bladder, rectum, and sigmoid colon (D2cc, D1cc, and D0.1cc). In addition, the V150 and V200 of irradiated tissue were compared for both eBT and HDR-BT. All patients received intensity-modulated external beam radiation therapy with a regimen of 23 sessions of 2 Gy followed by four sessions of 7 Gy of eBT performed over 2 weeks (two sessions followed by another two sessions a week later) following the EMBRACE recommendations. Each of the eight patients was followed to assess acute toxicity associated with treatment. Results: The doses reaching OAR for eBT plans were lower than for HDR-BT plans. As for acute toxicity associated with eBT, very few cases of mucositis were detected. No cases of rectal toxicity and one case with grade 1 urinary toxicity were detected. The results at 1 month are equally good, and no relapses have occurred to date. Conclusions: The first results of treatment with the Axxent eBT device are promising, as no recurrences have been observed and toxicity is very low. eBT is a good alternative for treating cervical cancer in centers without access to conventional HDR. 000086375 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000086375 590__ $$a1.679$$b2019 000086375 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b94 / 133 = 0.707$$c2019$$dQ3$$eT3 000086375 592__ $$a0.681$$b2019 000086375 593__ $$aInstrumentation$$c2019$$dQ1 000086375 593__ $$aRadiation$$c2019$$dQ2 000086375 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2019$$dQ2 000086375 593__ $$aMedicine (miscellaneous)$$c2019$$dQ2 000086375 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000086375 700__ $$0(orcid)0000-0003-4732-7409$$aFont-Gómez, José Antonio$$uUniversidad de Zaragoza 000086375 700__ $$aGandía-Martínez, Almundena 000086375 700__ $$aMiranda-Burgos, Anabela 000086375 700__ $$aMéndez-Villamón, Agustina$$uUniversidad de Zaragoza 000086375 700__ $$aVilla-Gazulla, David 000086375 700__ $$aAlba-Escorihuela, Verónica 000086375 700__ $$aJiménez-Puertas, Sara 000086375 700__ $$aGonzález-Pérez, Víctor 000086375 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física 000086375 773__ $$g20, 7 (2019), 78-86$$pJournal of Applied Clinical Medical Physics$$tJournal of Applied Clinical Medical Physics$$x1526-9914 000086375 8564_ $$s385909$$uhttps://zaguan.unizar.es/record/86375/files/texto_completo.pdf$$yVersión publicada 000086375 8564_ $$s90608$$uhttps://zaguan.unizar.es/record/86375/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000086375 909CO $$ooai:zaguan.unizar.es:86375$$particulos$$pdriver 000086375 951__ $$a2020-07-16-09:51:07 000086375 980__ $$aARTICLE