86389 20200716101601.0 doi 10.3390/cancers11060780 sideral 115081 ART-2019-115081 eng Mármol, Inés Universidad de Zaragoza Gold as a possible alternative to platinum-based chemotherapy for colon cancer treatment 2019 Access copy available to the general public Unrestricted Due to the increasing incidence and high mortality associated with colorectal cancer (CRC), novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is based on oxaliplatin and other cisplatin analogues; however, platinum-based therapy lacks selectivity to cancer cells and leads to deleterious side effects. In addition, tumor resistance to oxaliplatin is related to chemotherapy failure. Gold(I) derivatives are a promising alternative to platinum complexes, since instead of interacting with DNA, they target proteins overexpressed on tumor cells, thus leading to less side effects than, but a comparable antitumor effect to, platinum derivatives. Moreover, given the huge potential of gold nanoparticles, the role of gold in CRC chemotherapy is not limited to gold(I) complexes. Gold nanoparticles have been found to be able to overcome multidrug resistance along with reduced side effects due to a more efficient uptake of classic drugs. Moreover, the use of gold nanoparticles has enhanced the effect of traditional therapies such as radiotherapy, photothermal therapy, or photodynamic therapy, and has displayed a potential role in diagnosis as a consequence of their optic properties. Herein, we have reviewed the most recent advances in the use of gold(I) derivatives and gold nanoparticles in CRC therapy. info:eu-repo/grantAgreement/ES/DGA/B16-R17 info:eu-repo/grantAgreement/ES/DGA/E07-17R info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.126 2019 ONCOLOGY 37 / 244 = 0.152 2019 Q1 T1 1.938 2019 Oncology 2019 Q1 Cancer Research 2019 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Quero, Javier (orcid)0000-0002-3595-7668 Rodríguez-Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0003-2457-3674 Cerrada, Elena Universidad de Zaragoza 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 11, 6 (2019), 780 [36 pp.] Cancers Cancers 2072-6694 929525 http://zaguan.unizar.es/record/86389/files/texto_completo.pdf Versión publicada 107859 http://zaguan.unizar.es/record/86389/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:86389 articulos driver 2020-07-16-09:53:00 ARTICLE