000086390 001__ 86390
000086390 005__ 20220525082806.0
000086390 0247_ $$2doi$$a10.3390/nu11061340
000086390 0248_ $$2sideral$$a115082
000086390 037__ $$aART-2019-115082
000086390 041__ $$aeng
000086390 100__ $$aBarja-Fernández S.
000086390 245__ $$aANGPTL-4 is associated with obesity and lipid profile in children and adolescents
000086390 260__ $$c2019
000086390 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086390 5203_ $$aAngiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.
000086390 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-00998$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-01272$$9info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042
000086390 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000086390 590__ $$a4.546$$b2019
000086390 591__ $$aNUTRITION & DIETETICS$$b17 / 89 = 0.191$$c2019$$dQ1$$eT1
000086390 592__ $$a1.329$$b2019
000086390 593__ $$aNutrition and Dietetics$$c2019$$dQ1
000086390 593__ $$aFood Science$$c2019$$dQ1
000086390 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086390 700__ $$aFolgueira C.
000086390 700__ $$aCastelao C.
000086390 700__ $$aPena-León V.
000086390 700__ $$aGonzález-Saenz P.
000086390 700__ $$aVázquez-Cobela R.
000086390 700__ $$aAguilera C.M.
000086390 700__ $$aGil-Campos M.
000086390 700__ $$0(orcid)0000-0002-0902-387X$$aBueno G.$$uUniversidad de Zaragoza
000086390 700__ $$aGil Á.
000086390 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno L.A.$$uUniversidad de Zaragoza
000086390 700__ $$aRuiz-Piñon M.
000086390 700__ $$aGarcía-Palacios M.
000086390 700__ $$aCasanueva F.F.
000086390 700__ $$aDiéguez C.
000086390 700__ $$aNogueiras R.
000086390 700__ $$aLeis R.
000086390 700__ $$aSeoane L.M.
000086390 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000086390 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
000086390 773__ $$g11, 6 (2019), 1340 [14 pp.]$$pNUTRIENTS$$tNUTRIENTS$$x2072-6643
000086390 8564_ $$s649891$$uhttps://zaguan.unizar.es/record/86390/files/texto_completo.pdf$$yVersión publicada
000086390 8564_ $$s110758$$uhttps://zaguan.unizar.es/record/86390/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086390 909CO $$ooai:zaguan.unizar.es:86390$$particulos$$pdriver
000086390 951__ $$a2022-05-25-08:25:29
000086390 980__ $$aARTICLE